新近发病的ACPA阳性和ACPA阴性RA的前足炎症:临床症状相似,但潜在炎症组织不同。

IF 5.1 2区 医学 Q1 RHEUMATOLOGY
Dennis A Ton, Bastiaan T van Dijk, Hanna W van Steenbergen, Annette H M van der Helm-van Mil
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引用次数: 0

摘要

目的:尽管关节肿胀传统上被解释为滑膜炎,但最近的影像学研究表明,前足的腱鞘和跖间滑囊也存在炎症。我们旨在进一步了解 ACPA 阳性和 ACPA 阴性类风湿性关节炎(RA)确诊时前足受累情况的异同。因此,我们(1)比较了ACPA组间的跖趾关节(MTP)数量、行走障碍和炎症组织;(2)研究了ACPA组内关节肿胀/触痛和行走障碍与潜在炎症组织的关联。方法:171名ACPA阳性和203名ACPA阴性连续确诊的RA患者接受了关节体检(关节肿胀数量-66/关节触痛数量-68),填写了包括行走领域在内的健康评估问卷,并在确诊时接受了MTP关节核磁共振成像检查。对滑膜炎、腱鞘炎、骨炎和跖间滑囊炎(IMB)进行了评估。结果显示,ACPA阴性的患者在MTP关节上会出现异常,而ACPA阳性的患者在MTP关节上不会出现异常:虽然ACPA阴性的RA患者有更多的关节肿胀(平均SJC为8,ACPA阳性为6,P=0.003),但MTP关节肿胀的数量相似(两组平均为1);行走障碍也同样常见(49%对53%)。相反,与ACPA阴性RA相比,ACPA阳性RA的炎症组织更为普遍。在 ACPA 阳性的 RA 患者中,IMB 与 MTP 关节肿胀(OR 2.6,95% CI 1.4 至 5.0)和压痛(OR 3.0,95% CI 1.8 至 5.0)独立相关。而在 ACPA 阴性患者中,滑膜炎与 MTP 关节肿胀(OR 2.8,95% CI 1.4 至 5.8)和压痛(OR 2.5,95% CI 1.3 至 4.8)独立相关。腱鞘炎是造成行走障碍的主要原因:结论:虽然ACPA阳性和ACPA阴性患者的前足在诊断时具有相似的临床表现,但其潜在的炎症组织却存在差异。这进一步说明ACPA阳性和ACPA阴性RA是不同的实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Forefoot inflammation in recent-onset ACPA-positive and ACPA-negative RA: clinically similar, but different in underlying inflamed tissues.

Objectives: Although joint swelling is traditionally interpreted as synovitis, recent imaging studies showed that there is also inflammation of tenosynovium and intermetatarsal bursae in the forefoot. We aimed to increase our understanding of differences and similarities regarding forefoot involvement between ACPA-positive and ACPA-negative rheumatoid arthritis (RA) at diagnosis. Therefore, we (1) compared metatarsophalangeal (MTP) joint counts, walking disabilities and inflamed tissues between ACPA groups and (2) studied associations of joint swelling/tenderness and walking disabilities with underlying inflamed tissues within ACPA groups.

Methods: 171 ACPA-positive and 203 ACPA-negative consecutively diagnosed patients with RA had a physical joint examination (swollen joint count-66/tender joint count-68), filled a Health Assessment Questionnaire including the domain walking and underwent MRI of the MTP joints at diagnosis. Synovitis, tenosynovitis, osteitis and intermetatarsal bursitis (IMB) were assessed. Findings in age-matched healthy controls were applied to define abnormalities on MRI.

Results: While ACPA-negative RA patients had more swollen joints (mean SJC 8 vs 6 in ACPA-positives, p=0.003), the number of swollen MTP joints was similar (mean 1 in both groups); walking disabilities were also equally common (49% vs 53%). In contrast, inflamed tissues were all more prevalent in ACPA-positive compared with ACPA-negative RA. Within ACPA-positive RA, IMB was associated independently with MTP-joint swelling (OR 2.6, 95% CI 1.4 to 5.0) and tenderness (OR 3.0, 95% CI 1.8 to 5.0). While in ACPA-negatives, synovitis was associated independently with MTP-joint swelling (OR 2.8, 95% CI 1.4 to 5.8) and tenderness (OR 2.5, 95% CI 1.3 to 4.8). Tenosynovitis contributed most to walking disabilities.

Conclusions: Although the forefoot of ACPA-positives and ACPA-negatives share clinical similarities at diagnosis, there are differences in underlying inflamed tissues. This reinforces that ACPA-positive and ACPA-negative RA are different entities.

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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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