作为巴西心脏保护饮食一部分的混合坚果对心肌梗塞后成年患者低密度脂蛋白胆固醇的影响:一项多中心随机对照临床试验。

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Ângela Cristine Bersch-Ferreira, Camila Weschenfelder, Rachel Helena Vieira Machado, Renato Hideo Nakagawa Santos, Terrence M Riley, Lucas Ribeiro da Silva, Debora Harumi Kodama Miyada, Erica Regina Ribeiro Sady, Erlon Oliveira de Abreu-Silva, Ligia Nasi Laranjeira, Alexandre Schaan de Quadros, Júlia Lorenzon Dos Santos, Gabriela Corrêa Souza, Suena Medeiros Parahiba, Ana Paula Trussardi Fayh, Danielle Soares Bezerra, Ana Paula Perillo Ferreira Carvalho, Malaine Morais Alves Machado, Sandra Mary Lima Vasconcelos, Mayranne Victórya Rocha Santos, José Albuquerque de Figueiredo Neto, Luciana Pereira Pinto Dias, Francisca Eugenia Zaina Nagano, Cássia Cristina Paes de Almeida, Annie Seixas Bello Moreira, Rodrigo Damasceno de Oliveira, Marcelo Macedo Rogero, Geni Rodrigues Sampaio, Elizabeth Aparecida Ferraz da Silva Torres, Bernardete Weber, Alexandre Biasi Cavalcanti, Aline Marcadenti
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引用次数: 0

摘要

背景:坚果的食用与心血管一级预防中的心血管保护作用有关,但针对二级预防的研究却很少且存在争议。本试验的目的是评估区域性和可持续的心血管保护饮食中是否添加了经济实惠的混合坚果对既往心肌梗死患者心血管代谢特征的影响:DICA-NUTS 研究是一项全国性、多中心、优势平行的随机临床试验。研究对象包括 40 岁以上、在过去 2 至 6 个月内被诊断为曾患心肌梗死的男性和女性。患者被分为两组:巴西心脏保护饮食(DICA Br),每天补充 30 克混合坚果(10 克花生;10 克腰果;10 克巴西坚果)(干预组,n = 193);或仅 DICA Br 处方(对照组,n = 195)。主要结果是 16 周后低密度脂蛋白胆固醇的平均值(毫克/分升)。次要结果为其他血脂生物标志物、血糖和人体测量数据以及饮食质量:在对基线值、参与研究的地点、心肌梗死后的时间和他汀类药物治疗方案(高效、中效和低效/无他汀类药物)进行调整后,发现两组间的低密度脂蛋白胆固醇浓度无显著差异(干预组与对照组的差异:3.48 mg/dL [-3.45 至 10.41],P = 0.32)。研究结束时,两组的总体饮食质量都有所改善,16 周后无差异(干预组与对照组差异:1.05(-0.9 至 10.41)毫克/分升):1.05(-0.9 至 2.99);P = 0.29)。其他血脂、血糖和人体测量指标在研究结束时在研究组之间也没有差异:结论:在 DICA Br 中添加 30 克/天的混合坚果,并持续 16 周,不会改变心肌梗死后的血脂、血糖和人体测量特征:本研究已在ClinicalTrials.gov网站注册,编号为NCT03728127,世界卫生组织通用试验编号(WHO-UTN)为U1111-1259-8105。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial.

Background: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction.

Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial. Males and females over 40 years old diagnosed with previous myocardial infarction in the last 2 to 6 months were included. Patients were allocated into two groups: the Brazilian Cardioprotective diet (DICA Br) supplemented with 30 g/day of mixed nuts (10 g of peanuts; 10 g of cashew; 10 g of Brazil nuts) (intervention group, n = 193); or only DICA Br prescription (control group, n = 195). The primary outcome was low-density lipoprotein cholesterol means (in mg/dL) after 16 weeks. Secondary outcomes were other lipid biomarkers, glycemic and anthropometric data and diet quality.

Results: After adjustment for baseline values, participating study site, time since myocardial infarction and statin treatment regimen (high potency, moderate and low potency/no statins), no significant difference was found between the groups in low-density lipoprotein cholesterol concentrations (intervention-control difference: 3.48 mg/dL [-3.45 to 10.41], P = 0.32). Both groups improved their overall diet quality at the end of the study without differences between them after 16 weeks (intervention-control difference: 1.05 (-0.9 to 2.99); P = 0.29). Other lipids, glycemic profile and anthropometrics were also not different between study groups at the end of the study.

Conclusion: Adding 30 g/day of mixed nuts to the DICA Br for 16 weeks did not change lipid, glycemic and anthropometric features in the post-myocardial infarction setting.

Trial registration: This study is registered on ClinicalTrials.gov website under number NCT03728127 and its World Health Organization Universal Trial Number (WHO-UTN) is U1111-1259-8105.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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