TDP-43 核凝聚与神经退行性蛋白病。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI:10.1016/j.tins.2024.09.003

Florencia Vassallu, Lionel M Igaz

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引用次数: 0

摘要

RNA 结合蛋白（RBPs）会发生相分离并形成凝聚物，而这一过程反过来又对其功能至关重要。在最近的一项研究中，Huang、Ellis 及其同事表明，细胞应激可引发核 TAR DNA 结合蛋白 43（TDP-43）的瞬时改变，从而导致对神经元正常功能至关重要的变化。这些发现对理解神经系统 TDP-43 蛋白病症具有重要意义。

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TDP-43 nuclear condensation and neurodegenerative proteinopathies.

RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43), leading to changes crucial for proper neuronal function. These findings have implications for understanding neurological TDP-43 proteinopathies.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.