基于磁感应断层扫描的腹腔出血模拟研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ruijuan Chen, Yalin Du, Xinlei Zhu, Yuanxin Zhang, Huiquan Wang, Hongsheng Sun, Jinhai Wang
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引用次数: 0

摘要

腹腔出血是一种重要的临床疾病,严重时可危及生命。因此,及时发现和治疗腹腔出血对患者的健康和安全至关重要。磁感应断层扫描是一种无创、无放射性、非接触式的电磁成像技术,在疾病筛查和连续监测方面具有潜在的应用价值。本文构建了接近真实人体腹部组织的电阻抗分布仿真模型,并基于该模型,采用有限元数值方法研究了内出血的磁感应断层成像仿真方法,并通过人体模型实验进行了对比验证。求解了腹腔组织内部的涡流密度分布和组织边界的磁感应相位数据,并对出血体积半径和位置变化引起的相位差进行了灵敏度分析,提出了三个灵敏度指标。模拟和模型实验均表明,当腹部有六种不同导电率的组织时,出血半径从 10 mm 增加到 30 mm,半径相位差灵敏度指标 Ar 近似线性单调增加。其半径变换灵敏度 Kr 为 3.0961 × 10-5°/cm。当出血量的位置发生变化时,X 轴位移相位差灵敏度指数 Ax 呈类线性单调下降,X 轴位移灵敏度 Kx 为 -6.3744 × 10-6°/cm。y 轴位移相位差灵敏度 Ay 指数呈类线性关系,单调递增,y 轴位移灵敏度 Ky 为 5.2870 × 10-4°/cm。结果表明,出血发生前后的相位差灵敏度可作为定量监测指标,监测腹腔内出血的发生及趋势,为利用磁感应成像技术初步筛查和持续监测腹腔出血疾病奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simulation study of abdominal hemorrhage based on magnetic induction tomography.

Abdominal hemorrhage is an important clinical disease that can be life-threatening in severe cases. Therefore, timely detection and treatment of abdominal hemorrhage is crucial for the health and safety of patients. Magnetic induction tomography is a non-invasive, nonradioactive, and non-contact electromagnetic imaging technology with potential application value for disease screening and continuous monitoring. In this paper, a simulation model of electrical impedance distribution close to the real human abdominal tissue was constructed, and based on this model, the magnetic induction tomography simulation method of internal bleeding was studied by the finite element numerical method, and the comparison was verified by phantom experiments. The eddy current density distribution inside the abdominal tissue and the magnetic induction phase data at the tissue boundary are solved, and sensitivity analysis of phase differences caused by changes in the radius and position of bleeding volume was conducted, and three sensitivity indicators were proposed. Both the simulation and phantom experiment show that when there are six types of tissues with different conductivity in the abdomen, the radius of bleeding increases from 10 to 30 mm, and the radius phase difference sensitivity index Ar increases approximately linearly monotonically. Its radius transformation sensitivity Kr is 3.0961 × 10-5°/cm. When the position of the bleeding volume changes, the sensitivity index Ax of the x-axis displacement phase difference shows a quasilinear monotonic decrease, and the x-axis displacement sensitivity Kx is -6.3744 × 10-6°/cm. The y-axis displacement phase difference sensitivity Ay index shows a quasilinear relationship and monotonically increases, with a y-axis displacement sensitivity Ky of 5.2870 × 10-4°/cm. The results indicate that the phase difference sensitivity before and after the occurrence of bleeding can be used as a quantitative monitoring indicator to monitor the occurrence and trend of intra-abdominal hemorrhage, laying the foundation for the preliminary screening and continuous monitoring of abdominal hemorrhage diseases using magnetic induction imaging.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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