啮齿动物操作学习中的行动和价值信息适应回路

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sato
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引用次数: 0

摘要

操作性学习是一种行为范式,在这种范式中,动物学会将自己的行为与后果联系起来,并据此调整自己的行为。这篇综述深入探讨了支撑啮齿动物操作性学习的神经回路,强调了神经通路、突触可塑性和基因表达变化之间的动态相互作用。我们探讨了皮质-基底神经节回路,强调了多巴胺在调节这些通路以强化产生积极结果的行为方面的关键作用。最近的研究揭示了中脑多巴胺神经元在整合行动启动和奖赏反馈方面的复杂作用,从而增强了背侧纹状体中与运动相关的活动。此外,我们还讨论了纹状体神经元的分子多样性及其在强化学习中的特定作用。该综述还涵盖了转录组分析技术(如单细胞 RNA 测序)的进展,这些技术为深入了解操作学习过程中与不同神经元群相关的基因表达谱提供了机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adaptive circuits for action and value information in rodent operant learning.

Operant learning is a behavioral paradigm where animals learn to associate their actions with consequences, adapting their behavior accordingly. This review delves into the neural circuits that underpin operant learning in rodents, emphasizing the dynamic interplay between neural pathways, synaptic plasticity, and gene expression changes. We explore the cortico-basal ganglia circuits, highlighting the pivotal role of dopamine in modulating these pathways to reinforce behaviors that yield positive outcomes. We include insights from recent studies, which reveals the intricate roles of midbrain dopamine neurons in integrating action initiation and reward feedback, thereby enhancing movement-related activities in the dorsal striatum. Additionally, we discuss the molecular diversity of striatal neurons and their specific roles in reinforcement learning. The review also covers advances in transcriptome analysis techniques, such as single-cell RNA sequencing, which have provided deeper insights into the gene expression profiles associated with different neuronal populations during operant learning.

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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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