老化的 B 细胞中潜伏着淋巴瘤。

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2024-09-30 DOI:10.1038/s43587-024-00714-z

Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero

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引用次数: 0

摘要

癌症与衰老密不可分。然而，癌症究竟是衰老过程的副产品，还是衰老细胞本身就容易发生肿瘤，这仍然是个谜。卡斯特罗、辛迪亚皮纳及其同事的一项研究证明，在自发罹患淋巴瘤的老年小鼠中，肿瘤来源于克隆扩增的老年相关 B 细胞，从而为后者提供了佐证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lymphoma lurks within aged B cells

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Lymphoma lurks within aged B cells

Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.

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来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

发文量