老化的 B 细胞中潜伏着淋巴瘤。

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2024-09-30 DOI:10.1038/s43587-024-00714-z

Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero

{"title":"老化的 B 细胞中潜伏着淋巴瘤。","authors":"Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero","doi":"10.1038/s43587-024-00714-z","DOIUrl":null,"url":null,"abstract":"Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1343-1345"},"PeriodicalIF":17.0000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lymphoma lurks within aged B cells\",\"authors\":\"Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero\",\"doi\":\"10.1038/s43587-024-00714-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 10\",\"pages\":\"1343-1345\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00714-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00714-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

癌症与衰老密不可分。然而，癌症究竟是衰老过程的副产品，还是衰老细胞本身就容易发生肿瘤，这仍然是个谜。卡斯特罗、辛迪亚皮纳及其同事的一项研究证明，在自发罹患淋巴瘤的老年小鼠中，肿瘤来源于克隆扩增的老年相关 B 细胞，从而为后者提供了佐证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lymphoma lurks within aged B cells

查看原文本刊更多论文

Lymphoma lurks within aged B cells

Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

发文量