痴呆症患者疑似感染的检测和管理--对当前做法的范围审查。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-24 DOI:10.1016/j.arr.2024.102520

Mihaela Ivosevic , Gritt Overbeck , Anne Holm , Gunhild Waldemar , Janet Janbek

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引用次数: 0

摘要

痴呆症患者因感染而住院和死亡的风险增加。我们旨在探讨检测和管理痴呆症患者疑似感染的决策过程和干预措施，以及相关参与者和决定因素。我们通过检索 CINAHL 和 PubMed 进行了范围界定综述，并通过绘图和叙述的方式对数据进行了综合。我们确定了 22 项研究，其中大部分基于疗养院和美国数据。决策过程包括根据早期体征和症状的观察识别感染、怀疑感染时采取的行动以及代理/家人的参与。干预措施包括抗菌药物管理和其他决策支持工具。决定因素包括医护人员的看法以及其他系统/个人相关因素。医护人员是主要参与者，很少提及代理/家人，而痴呆症患者仅被提及过一次。我们的研究结果表明，有关痴呆症患者和疗养院外的证据很少。我们强调了知识差距，并为改进感染检测和管理的干预措施研究提供了参考。

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Detection and management of suspected infections in people with dementia – A scoping review of current practices

People with dementia have an increased risk of hospitalization and mortality due to infections. We aimed to explore decision-making processes and interventions for detecting and managing suspected infections in people with dementia and involved actors and determinants. We conducted a scoping review, searching CINAHL and PubMed, and synthesized data through mapping and narratively. We identified 22 studies, based mostly on nursing homes and US data. Decision-making processes included recognition of infections based on observations of early signs and symptoms, actions when suspecting infections, and proxy/family involvement. Interventions included antimicrobial stewardship and other decision-support tools. Determinants included healthcare staff perceptions, and other system/person-related factors. Healthcare staff were the main actors, proxy/family were mentioned scarcely, and people with dementia only once. Our findings show scarcity of evidence on people with dementia and outside of the nursing homes. We highlight knowledge gaps and inform research shaping interventions for improving infection detection and management.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.