Biomedical applications and nutritional value of specific food-derived polysaccharide-based hydrogels.

Food-derived polysaccharide-based hydrogels (FPBHs), which are composed of polysaccharides derived from food sources exhibit great potential for biomedical applications. The FPBHs possess a wide range of biological activities and can be utilized in the treatment of various clinical diseases. However, the majority of research efforts have predominantly focused on non-specific polysaccharides derived from various sources (most plants, animals, and microorganisms), while the exploration of hydrogels originating from specific polysaccharides with distinct bioactivity extracted from natural food sources remains limited. In this review, a comprehensive search was conducted across three major databases (PubMed, Web of Science, and Medline) until 7^th Apr 2024 to include 32 studies that employed FPBHs for biomedical applications. This review provides an overview of hydrogels based on specific food-derived polysaccharides by summarizing their types, sources, molecular weight, monosaccharide composition and biological activities. The crosslinking strategies employed in the fabrication of FPBHs were demonstrated. The attributes and characteristics of FPBHs were delined, including their physical, chemical, and functional properties. Of particular note, the review highlights in vivo and in vitro studies exploring the biomedical applications of FPBHs and delve into the nutritional value of specific food-derived polysaccharides. The challenges encountered in basic research involving FPBHs were enumerated as well as limitation in their clinical practice. Finally, the potential market outlook for FPBHs in the future was also discussed.