Dae-Won Ki*, Ji-Yul Kim, Young-Hee Lee, Dae-Cheol Choi, Ho-Keun Yi, In-Kyoung Lee and Bong-Sik Yun*,
{"title":"髓苷 A-H（来自秘鲁髓苷的倍半萜）及其在 HDF 细胞中的细胞信号机制","authors":"Dae-Won Ki*, Ji-Yul Kim, Young-Hee Lee, Dae-Cheol Choi, Ho-Keun Yi, In-Kyoung Lee and Bong-Sik Yun*, ","doi":"10.1021/acs.jnatprod.4c0043610.1021/acs.jnatprod.4c00436","DOIUrl":null,"url":null,"abstract":"<p >A chemical investigation of an ethyl acetate-soluble layer in the culture broth of <i>Perenniporia medulla-panis</i> resulted in the isolation of eight novel sesquiterpenes conjugated Gly (<b>1</b>), <span>l</span>-Val (<b>2</b>), <span>l</span>-Ala (<b>3</b>), <span>l</span>-Tyr (<b>4</b>), <span>l</span>-Thr (<b>5</b>), <span>l</span>-Ile (<b>6</b>), <span>l</span>-Leu (<b>7</b>), and <span>l</span>-Phe (<b>8</b>). Elucidation of their structures was performed through comprehensive spectroscopic analysis. The absolute configuration of the sesquiterpene skeleton was ascertained using modified Mosher’s methods. The configurations of the amino acid units in compounds <b>2</b>–<b>8</b> were identified through acid hydrolysis followed by LC-MS analysis employing Marfey’s method. Compounds <b>1</b>–<b>3</b> and <b>5</b>–<b>8</b> showed significant regulating effect on MAP kinase activity (p-ERK and p-JNK) in human diploid fibroblast (HDF) cells.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"87 9","pages":"2194–2203 2194–2203"},"PeriodicalIF":3.3000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Medullins A-H, Sesquiterpenes from Perenniporia medulla-panis, and Their Cellular Signaling Mechanism in HDF Cells\",\"authors\":\"Dae-Won Ki*, Ji-Yul Kim, Young-Hee Lee, Dae-Cheol Choi, Ho-Keun Yi, In-Kyoung Lee and Bong-Sik Yun*, \",\"doi\":\"10.1021/acs.jnatprod.4c0043610.1021/acs.jnatprod.4c00436\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A chemical investigation of an ethyl acetate-soluble layer in the culture broth of <i>Perenniporia medulla-panis</i> resulted in the isolation of eight novel sesquiterpenes conjugated Gly (<b>1</b>), <span>l</span>-Val (<b>2</b>), <span>l</span>-Ala (<b>3</b>), <span>l</span>-Tyr (<b>4</b>), <span>l</span>-Thr (<b>5</b>), <span>l</span>-Ile (<b>6</b>), <span>l</span>-Leu (<b>7</b>), and <span>l</span>-Phe (<b>8</b>). Elucidation of their structures was performed through comprehensive spectroscopic analysis. The absolute configuration of the sesquiterpene skeleton was ascertained using modified Mosher’s methods. The configurations of the amino acid units in compounds <b>2</b>–<b>8</b> were identified through acid hydrolysis followed by LC-MS analysis employing Marfey’s method. Compounds <b>1</b>–<b>3</b> and <b>5</b>–<b>8</b> showed significant regulating effect on MAP kinase activity (p-ERK and p-JNK) in human diploid fibroblast (HDF) cells.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\"87 9\",\"pages\":\"2194–2203 2194–2203\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00436\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00436","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Medullins A-H, Sesquiterpenes from Perenniporia medulla-panis, and Their Cellular Signaling Mechanism in HDF Cells
A chemical investigation of an ethyl acetate-soluble layer in the culture broth of Perenniporia medulla-panis resulted in the isolation of eight novel sesquiterpenes conjugated Gly (1), l-Val (2), l-Ala (3), l-Tyr (4), l-Thr (5), l-Ile (6), l-Leu (7), and l-Phe (8). Elucidation of their structures was performed through comprehensive spectroscopic analysis. The absolute configuration of the sesquiterpene skeleton was ascertained using modified Mosher’s methods. The configurations of the amino acid units in compounds 2–8 were identified through acid hydrolysis followed by LC-MS analysis employing Marfey’s method. Compounds 1–3 and 5–8 showed significant regulating effect on MAP kinase activity (p-ERK and p-JNK) in human diploid fibroblast (HDF) cells.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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