{"title":"数据收集、危害特征描述以及针对农药对甲状腺的特定影响建立累积评估组：2024 年更新版","authors":"Francesca Metruccio, Ilaria Castelli, Alessandra Baroni, Martina Marazzini, Teresa Mammone, Luca Tosti","doi":"10.2903/sp.efsa.2024.EN-9012","DOIUrl":null,"url":null,"abstract":"<p>This report evaluates the thyroid-related effects of various active substances and metabolites, categorizing them into Cumulative Assessment Groups (CAGs) based on indicators of hypothyroidism and C-cell effects. 21 active substances and six metabolites were scrutinized resulting in 18 substances and three metabolites for hypothyroidism (CAG-TCF) and two substances for C-cell hypertrophy, hyperplasia, and neoplasia (CAG-TCP). Detailed NOAEL and LOAEL values were derived for each substance, highlighting differences between current findings and previous assessments. The analysis reveals uncertainties due to variations in data quality and study durations. Overall, the report provides a comprehensive hazard characterization of substances affecting thyroid function, contributing to cumulative risk assessment update for effects on the thyroid.</p>","PeriodicalId":100395,"journal":{"name":"EFSA Supporting Publications","volume":"21 9","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2024.EN-9012","citationCount":"0","resultStr":"{\"title\":\"Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update\",\"authors\":\"Francesca Metruccio, Ilaria Castelli, Alessandra Baroni, Martina Marazzini, Teresa Mammone, Luca Tosti\",\"doi\":\"10.2903/sp.efsa.2024.EN-9012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This report evaluates the thyroid-related effects of various active substances and metabolites, categorizing them into Cumulative Assessment Groups (CAGs) based on indicators of hypothyroidism and C-cell effects. 21 active substances and six metabolites were scrutinized resulting in 18 substances and three metabolites for hypothyroidism (CAG-TCF) and two substances for C-cell hypertrophy, hyperplasia, and neoplasia (CAG-TCP). Detailed NOAEL and LOAEL values were derived for each substance, highlighting differences between current findings and previous assessments. The analysis reveals uncertainties due to variations in data quality and study durations. Overall, the report provides a comprehensive hazard characterization of substances affecting thyroid function, contributing to cumulative risk assessment update for effects on the thyroid.</p>\",\"PeriodicalId\":100395,\"journal\":{\"name\":\"EFSA Supporting Publications\",\"volume\":\"21 9\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2024.EN-9012\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EFSA Supporting Publications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2024.EN-9012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EFSA Supporting Publications","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2024.EN-9012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本报告评估了各种活性物质和代谢物与甲状腺有关的影响，并根据甲状腺功能减退和 C 细胞影响的指标将它们分为累积评估组 (CAG)。对 21 种活性物质和 6 种代谢物进行了仔细研究，得出了 18 种物质和 3 种代谢物对甲状腺功能减退的影响（CAG-TCF），以及 2 种物质对 C 细胞肥大、增生和肿瘤的影响（CAG-TCP）。为每种物质得出了详细的无观测不良效应水平（NOAEL）和最低观测不良效应水平（LOAEL）值，突出了当前研究结果与之前评估结果之间的差异。分析揭示了由于数据质量和研究持续时间的不同而造成的不确定性。总之，该报告全面描述了影响甲状腺功能的物质的危害特征，有助于更新对甲状腺影响的累积风险评估。
Data collection, hazard characterisation and establishment of cumulative assessment groups of pesticides for specific effects on the thyroid: 2024 update
This report evaluates the thyroid-related effects of various active substances and metabolites, categorizing them into Cumulative Assessment Groups (CAGs) based on indicators of hypothyroidism and C-cell effects. 21 active substances and six metabolites were scrutinized resulting in 18 substances and three metabolites for hypothyroidism (CAG-TCF) and two substances for C-cell hypertrophy, hyperplasia, and neoplasia (CAG-TCP). Detailed NOAEL and LOAEL values were derived for each substance, highlighting differences between current findings and previous assessments. The analysis reveals uncertainties due to variations in data quality and study durations. Overall, the report provides a comprehensive hazard characterization of substances affecting thyroid function, contributing to cumulative risk assessment update for effects on the thyroid.
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