老龄化对 HIV-1 相关神经认知障碍的影响。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-21 DOI:10.1016/j.arr.2024.102513

Philipp Niklas Ostermann , Teresa Hope Evering

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引用次数: 0

摘要

根据研究人群的不同，尽管有联合抗逆转录病毒疗法（cART），但与 HIV-1 相关的神经认知障碍估计会影响多达一半的艾滋病病毒感染者（PLWH）。造成这种神经认知功能障碍的因素多种多样，这使得我们对相关分子机制的理解变得更加复杂。生物老化被认为是可能影响 HIV-1 相关神经认知障碍的发生和发展的一个因素。这一点越来越重要，因为目前预计接受 cART 治疗后病毒学抑制的 PLWH 患者的预期寿命将与未感染 HIV 的患者相似。基于我们对生物衰老过程在细胞水平上的理解不断加深，我们的目标是剖析衰老和 HIV-1 感染诱导的效应之间可能存在的相互作用及其在神经认知功能衰退中的作用。因此，我们首先简要概述了与 HIV-1 相关的神经认知障碍的临床方面，并回顾了老龄化与神经认知障碍发展相关的累积证据（第一部分）。然后，我们将在分子水平上讨论衰老相关途径与 HIV-1 引起的影响之间的潜在相互作用（第二部分）。

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The impact of aging on HIV-1-related neurocognitive impairment

Depending on the population studied, HIV-1-related neurocognitive impairment is estimated to impact up to half the population of people living with HIV (PLWH) despite the availability of combination antiretroviral therapy (cART). Various factors contribute to this neurocognitive impairment, which complicates our understanding of the molecular mechanisms involved. Biological aging has been implicated as one factor possibly impacting the development and progression of HIV-1-related neurocognitive impairment. This is increasingly important as the life expectancy of PLWH with virologic suppression on cART is currently projected to be similar to that of individuals not living with HIV. Based on our increasing understanding of the biological aging process on a cellular level, we aim to dissect possible interactions of aging- and HIV-1 infection-induced effects and their role in neurocognitive decline. Thus, we begin by providing a brief overview of the clinical aspects of HIV-1-related neurocognitive impairment and review the accumulating evidence implicating aging in its development (Part I). We then discuss potential interactions between aging-associated pathways and HIV-1-induced effects at the molecular level (Part II).

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.