线粒体在肿瘤转移中的作用以及线粒体靶向癌症疗法的进展。

IF 7.7 2区 医学 Q1 ONCOLOGY
Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI:10.1007/s10555-024-10211-9
Fanglu Chen, Yucheng Xue, Wenkan Zhang, Hao Zhou, Zhiyi Zhou, Tao Chen, Eloy YinWang, Hengyuan Li, Zhaoming Ye, Junjie Gao, Shengdong Wang
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引用次数: 0

摘要

线粒体是能量代谢、应激信号转导和免疫调节等多种生理现象的核心参与者。越来越多的科学证据表明,特定的线粒体相关事件(包括线粒体质量控制、细胞间线粒体转移和线粒体遗传学)在促进肿瘤细胞转移级联过程中起着至关重要的作用。此外,最近的许多研究都不断强调线粒体在协调肿瘤浸润免疫细胞的调控和免疫治疗干预方面发挥着非常重要的作用。本综述对这一主题进行了全面而严谨的学术研究,探讨了线粒体促进肿瘤转移的复杂机制,并研究了线粒体靶向癌症疗法的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy.

Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies.

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来源期刊
CiteScore
17.00
自引率
0.00%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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