Manickam Rajkumar, S. I. Davis Presley, Farid Menaa, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Aishah E. Albalawi, Norah A. Althobaiti, Dharmalingam Kirubakaran, Prabha Govindaraj, Krishnan Meenambigai, Thandapani Gomathi
{"title":"利用椴树叶提取物合成氢氧化镁纳米颗粒并提高其生物活性","authors":"Manickam Rajkumar, S. I. Davis Presley, Farid Menaa, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Aishah E. Albalawi, Norah A. Althobaiti, Dharmalingam Kirubakaran, Prabha Govindaraj, Krishnan Meenambigai, Thandapani Gomathi","doi":"10.1007/s00449-024-03089-y","DOIUrl":null,"url":null,"abstract":"<p>The synthesis of magnesium hydroxide nanoparticles (Mg(OH)<sub>2</sub> NPs) using plant extracts are known to be a practical, economical, and an environmentally friendly approach. In this work, Mg(OH)<sub>2</sub> NPs were synthesized using aqueous leaf extract of <i>Tinospora cordifolia</i>, a medicinal plant commonly found in India. The synthesized Mg(OH)<sub>2</sub> NPs were characterized using various spectroscopic techniques. The ultraviolet–visible (UV–Vis) absorption peak of the Mg(OH)<sub>2</sub> NPs was detected at 289 nm, Fourier transform infrared (FTIR) analysis confirmed the presence of various functional groups, and X-ray diffraction (XRD) patterns revealed the well-crystallized structure of the Mg(OH)<sub>2</sub> NPs. High-resolution transmission electron microscopy (HR-TEM) and scanning electron microscopy (SEM) analyses depicted spherical morphology and an average particle size (PS) of 27.71 nm. The energy-dispersive X-ray (EDX) analysis confirmed the presence of C, O, and Mg elements, and the X-ray photoelectron spectroscopy (XPS) survey spectrum confirmed the elements for the Su 1<i> s</i> peak at 280.2 eV. The dynamic light scattering (DLS) analysis displayed an average PS of 54.3 nm, and the Zeta potential (ZP) was of 9.89 mV. The fabricated Mg(OH)<sub>2</sub> NPs displayed notable antibacterial activity against <i>S. epidermidis</i>, <i>E. coli</i>, and <i>S. aureus</i>. In addition, these NPs exhibited strong antioxidant properties (> 75%) based on DPPH, ABTS, and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) assays. Further, the same NPs exerted a potent anti-inflammatory activity (> 65%) based on COX-1 and COX-2 evaluations. The anti-Alzheimer’ disease (AD) potential of Mg(OH)<sub>2</sub> NPs was assessed through effective inhibition (> 70%) of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Molecular docking (MD) studies confirmed that caryophyllene has higher binding affinity with AChE (−5.3 kcal/mol) and BuChE (−6.4 kcal/mol) enzymes. This study emphasizes the green synthesis of Mg(OH)<sub>2</sub> NPs using <i>T. cordifolia</i> as a plant source and highlights their potential for biomedical applications.</p>","PeriodicalId":9024,"journal":{"name":"Bioprocess and Biosystems Engineering","volume":"1 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract\",\"authors\":\"Manickam Rajkumar, S. I. Davis Presley, Farid Menaa, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Aishah E. Albalawi, Norah A. 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High-resolution transmission electron microscopy (HR-TEM) and scanning electron microscopy (SEM) analyses depicted spherical morphology and an average particle size (PS) of 27.71 nm. The energy-dispersive X-ray (EDX) analysis confirmed the presence of C, O, and Mg elements, and the X-ray photoelectron spectroscopy (XPS) survey spectrum confirmed the elements for the Su 1<i> s</i> peak at 280.2 eV. The dynamic light scattering (DLS) analysis displayed an average PS of 54.3 nm, and the Zeta potential (ZP) was of 9.89 mV. The fabricated Mg(OH)<sub>2</sub> NPs displayed notable antibacterial activity against <i>S. epidermidis</i>, <i>E. coli</i>, and <i>S. aureus</i>. In addition, these NPs exhibited strong antioxidant properties (> 75%) based on DPPH, ABTS, and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) assays. Further, the same NPs exerted a potent anti-inflammatory activity (> 65%) based on COX-1 and COX-2 evaluations. The anti-Alzheimer’ disease (AD) potential of Mg(OH)<sub>2</sub> NPs was assessed through effective inhibition (> 70%) of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Molecular docking (MD) studies confirmed that caryophyllene has higher binding affinity with AChE (−5.3 kcal/mol) and BuChE (−6.4 kcal/mol) enzymes. 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Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract
The synthesis of magnesium hydroxide nanoparticles (Mg(OH)2 NPs) using plant extracts are known to be a practical, economical, and an environmentally friendly approach. In this work, Mg(OH)2 NPs were synthesized using aqueous leaf extract of Tinospora cordifolia, a medicinal plant commonly found in India. The synthesized Mg(OH)2 NPs were characterized using various spectroscopic techniques. The ultraviolet–visible (UV–Vis) absorption peak of the Mg(OH)2 NPs was detected at 289 nm, Fourier transform infrared (FTIR) analysis confirmed the presence of various functional groups, and X-ray diffraction (XRD) patterns revealed the well-crystallized structure of the Mg(OH)2 NPs. High-resolution transmission electron microscopy (HR-TEM) and scanning electron microscopy (SEM) analyses depicted spherical morphology and an average particle size (PS) of 27.71 nm. The energy-dispersive X-ray (EDX) analysis confirmed the presence of C, O, and Mg elements, and the X-ray photoelectron spectroscopy (XPS) survey spectrum confirmed the elements for the Su 1 s peak at 280.2 eV. The dynamic light scattering (DLS) analysis displayed an average PS of 54.3 nm, and the Zeta potential (ZP) was of 9.89 mV. The fabricated Mg(OH)2 NPs displayed notable antibacterial activity against S. epidermidis, E. coli, and S. aureus. In addition, these NPs exhibited strong antioxidant properties (> 75%) based on DPPH, ABTS, and hydrogen peroxide (H2O2) assays. Further, the same NPs exerted a potent anti-inflammatory activity (> 65%) based on COX-1 and COX-2 evaluations. The anti-Alzheimer’ disease (AD) potential of Mg(OH)2 NPs was assessed through effective inhibition (> 70%) of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Molecular docking (MD) studies confirmed that caryophyllene has higher binding affinity with AChE (−5.3 kcal/mol) and BuChE (−6.4 kcal/mol) enzymes. This study emphasizes the green synthesis of Mg(OH)2 NPs using T. cordifolia as a plant source and highlights their potential for biomedical applications.
期刊介绍：
Bioprocess and Biosystems Engineering provides an international peer-reviewed forum to facilitate the discussion between engineering and biological science to find efficient solutions in the development and improvement of bioprocesses. The aim of the journal is to focus more attention on the multidisciplinary approaches for integrative bioprocess design. Of special interest are the rational manipulation of biosystems through metabolic engineering techniques to provide new biocatalysts as well as the model based design of bioprocesses (up-stream processing, bioreactor operation and downstream processing) that will lead to new and sustainable production processes.
Contributions are targeted at new approaches for rational and evolutive design of cellular systems by taking into account the environment and constraints of technical production processes, integration of recombinant technology and process design, as well as new hybrid intersections such as bioinformatics and process systems engineering. Manuscripts concerning the design, simulation, experimental validation, control, and economic as well as ecological evaluation of novel processes using biosystems or parts thereof (e.g., enzymes, microorganisms, mammalian cells, plant cells, or tissue), their related products, or technical devices are also encouraged.
The Editors will consider papers for publication based on novelty, their impact on biotechnological production and their contribution to the advancement of bioprocess and biosystems engineering science. Submission of papers dealing with routine aspects of bioprocess engineering (e.g., routine application of established methodologies, and description of established equipment) are discouraged.
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