葫芦巴(Trigonella foenum-graecum)的抗糖尿病潜力:治疗糖尿病的神奇草药

IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Dipto Kumer Sarker, Pallobi Ray, Ashit Kumar Dutta, Razina Rouf, Shaikh Jamal Uddin
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引用次数: 0

摘要

葫蘆巴(Trigonella foenum-graecum)是亞洲一種廣泛種植的膳食草藥,其種子傳統上被用於治療包括糖尿病在內的多種疾病。其种子和叶片含有多种化合物,这些化合物在调节其降糖效果方面发挥着重要作用。然而,迄今为止,还没有关于其抗糖尿病作用的广泛系统综述,重点介绍其分子机制和分离化合物。本综述的目的是通过重点研究其基本机制,总结葫芦巴及其分离化合物的临床前和临床抗糖尿病特性。本文检索了 PubMed、Google Scholar、Science Direct 和 Scopus 数据库中截至 2024 年 6 月的文章。临床前研究表明,葫芦巴的抗糖尿病作用主要与增强葡萄糖转运体 4 型(GLUT4)转位和己糖激酶活性、降低葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶活性、抑制α-淀粉酶和麦芽糖酶活性、保护β细胞和增加胰岛素释放有关。此外,少数研究还报道了它作为胰高血糖素样肽-1(GLP-1)调节剂、5′-AMPK 激活剂和二肽基肽酶-IV(DPP-IV)抑制剂的作用。进一步的临床试验表明,葫芦巴籽能改善血糖水平、胰岛素抵抗、胰岛素敏感性和血脂状况。这项研究强调了葫芦巴及其分离化合物抗糖尿病作用的重要证据,因此,葫芦巴可以作为一种潜在的糖尿病疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antidiabetic potential of fenugreek (Trigonella foenum-graecum): A magic herb for diabetes mellitus

Antidiabetic potential of fenugreek (Trigonella foenum-graecum): A magic herb for diabetes mellitus

Fenugreek (Trigonella foenum-graecum) is a widely grown dietary herb in Asia, and its seeds are traditionally used for several diseases, including diabetes. The seeds and leaves possess a variety of compounds that play an important role in regulating their hypoglycemic effect. However, so far, no extensive systematic review exists on its antidiabetic effect, highlighting the molecular mechanisms and isolated compounds. The purpose of this review is to summarize the preclinical and clinical antidiabetic properties of fenugreek and its isolated compounds by focusing on underlying mechanisms. PubMed, Google Scholar, Science Direct, and Scopus databases were searched to retrieve articles until June, 2024. Preclinical studies demonstrated that the antidiabetic effect of fenugreek was mostly associated with enhanced glucose transporter type-4 (GLUT4) translocation and hexokinase activity, decreased glucose-6-phosphatase and fructose-1,6-bisphosphatase activities, inhibited α-amylase and maltase activities, protected β cells, and increased insulin release. Furthermore, few studies have reported its role as a glucagon-like peptide-1 (GLP-1) modulator, 5′-AMP-activated kinase (AMPK) activator, and dipeptidyl peptidase-IV (DPP-IV) inhibitor. Further clinical trials showed that fenugreek seeds improved blood glucose levels, insulin resistance, insulin sensitivity, and lipid profiles. This study highlights significant evidence of the antidiabetic effect of fenugreek and its isolated compounds; therefore, it could be a potential therapy for diabetes.

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来源期刊
Food Science & Nutrition
Food Science & Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
5.10%
发文量
434
审稿时长
24 weeks
期刊介绍: Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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