最新姜黄素类似物及其抗氧化、抗炎和抗癌活性综述

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kirandeep Kaur, Ahmad K. Al-Khazaleh, Deep Jyoti Bhuyan, Feng Li, Chun Guang Li
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引用次数: 0

摘要

姜黄素是姜黄(Curcuma longa)的主要活性成分,已被证实具有多种生物活性。然而,姜黄素的溶解性和生物利用度低、代谢快以及泛检测干扰特性等挑战阻碍了其潜在的治疗应用。最近的研究进展旨在通过开发新型姜黄素类似物和改性物来克服这些局限性。这篇简短的综述对近期有关合成不同姜黄素类似物(包括金属复合物、纳米微粒和其他姜黄素衍生物)的研究进行了批判性评估,重点关注姜黄素及其修饰类似物的抗氧化、抗炎和抗癌作用。探索创新姜黄素衍生物为解决与姜黄素生物利用率和功效相关的挑战提供了有前景的策略,也为未来的研究方向提供了宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities
Curcumin, as the main active component of turmeric (Curcuma longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such as poor solubility and bioavailability, rapid metabolism, and pan-assay interference properties. Recent advancements have aimed to overcome these limitations by developing novel curcumin analogues and modifications. This brief review critically assesses recent studies on synthesising different curcumin analogues, including metal complexes, nano particulates, and other curcumin derivatives, focused on the antioxidant, anti-inflammatory, and anticancer effects of curcumin and its modified analogues. Exploring innovative curcumin derivatives offers promising strategies to address the challenges associated with its bioavailability and efficacy and valuable insights for future research directions.
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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