将胃食管反流病与多肽蚕豆蛋白联系起来:调节炎症、氧化应激和临床生化参数的新治疗策略

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alessio Ardizzone, Sarah Adriana Scuderi, Lelio Crupi, Michela Campolo, Irene Paterniti, Anna Paola Capra, Emanuela Esposito
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引用次数: 0

摘要

胃食管反流病(GERD)是最普遍的前肠疾病之一,影响着全球大部分人。最新研究表明,细胞因子、趋化因子和酶等炎症介质是导致胃食管反流病患者食管粘膜改变的关键因素。食管粘膜中各种细胞因子的表达很可能也会通过增加活性氧(ROS)和活性氮(RNS)的产生来诱导氧化应激。作为可能支持肠胃轴的体液制剂和肽能神经递质,蚕豆蛋白及其相关的蚕豆蛋白样肽--GRP(胃泌素释放肽)尚未得到充分研究。因此,考虑到所有这些假设,本研究旨在评估胃食管反流病理情况下,蚕豆蛋白对重建与炎症和氧化/亚硝基应激相关的生化指标的影响。研究人员对C57BL/6小鼠进行了为期56天的过度喂养和禁食诱导胃食管反流,然后用蚕豆蛋白(0.1、0.5和1毫克/千克)腹腔注射治疗7天,每天一次,奥美拉唑作为阳性对照。治疗7天后,对胃痛和炎症指标进行了评估。服用蚕豆苷后,腹痛明显减轻,蚕豆苷还成功地减少了炎症和氧化/亚硝基应激标记物,其作用方式与奥美拉唑相似。此外,由于胃平衡的恢复,蚕豆蛋白还能显著调节胃pH值。总之,这些观察结果表明,上调蚕豆蛋白和相互关联的肽是治疗胃食管反流病患者的一种很有前景的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Linking GERD and the Peptide Bombesin: A New Therapeutic Strategy to Modulate Inflammatory, Oxidative Stress and Clinical Biochemistry Parameters
Gastroesophageal reflux disease (GERD) represents one of the most prevalent foregut illnesses, affecting a large portion of individuals worldwide. Recent research has shown that inflammatory mediators such as cytokines, chemokines, and enzymes are crucial for causing esophageal mucosa alterations in GERD patients. It seems likely that the expression of various cytokines in the esophageal mucosa also induces oxidative stress by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). As humoral agents and peptidergic neurotransmitters that may support the enterogastric axis, bombesin and its related bombesin-like peptide, GRP (gastrin releasing peptide), have not been fully investigated. Therefore, considering all these assumptions, this study aimed to evaluate the influence of bombesin in reestablishing biochemical markers linked with inflammation and oxidative/nitrosative stress in GERD pathological settings. C57BL/6 mice were alternatively overfed and fasted for 56 days to induce GERD and then treated with bombesin (0.1, 0.5, and 1 mg/kg intraperitoneally) once daily for 7 days, and omeprazole was used as the positive control. After 7 days of treatment, gastric pain and inflammatory markers were evaluated. Abdominal pain was significantly reduced following bombesin administration, which was also successful in diminishing inflammatory and oxidative/nitrosative stress markers in a manner overlapping with omeprazole. Moreover, bombesin was also able to appreciably modulate gastric pH as a result of the restoration of gastric homeostasis. Overall, these observations indicated that the upregulation of bombesin and interconnected peptides is a promising alternative approach to treat GERD patients.
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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