利用物种特异性碱度值预测硫醇-二硫化物体系的抗氧化能力

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-08-29 DOI:10.3390/antiox13091053

Tamás Pálla, Béla Noszál, Arash Mirzahosseini

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引用次数: 0

摘要

维持生命系统氧化还原平衡的主要反应是硫醇的去质子化，然后将生成的硫醇氧化转化为二硫化物，从而减少有害的氧化剂。各种生物硫醇在进行共同依赖的去质子化和氧化还原过程中具有不同的分子特异性。本研究利用硫醇酸盐碱性与氧化性之间的已知相关性，量化硫醇-二硫化物抗氧化系统的抗氧化或还原能力以及 pH 值依赖性，以此作为一种工具，寻找适当的分子来对抗氧化应激。

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Prediction of Antioxidant Capacity of Thiolate–Disulfide Systems Using Species-Specific Basicity Values

The principal reactions that maintain redox homeostasis in living systems are the deprotonation of thiols, followed by the oxidative conversion of the produced thiolates into disulfides, which thus reduce the harmful oxidizing agents. The various biological thiols have different molecule-specific propensities to carry on the co-dependent deprotonation and redox processes. This study utilizes the known correlation between thiolate basicities and oxidizabilities, to quantify antioxidant or reducing capacities and pH-dependences of thiol–disulfide antioxidant systems, as a tool to find adequate molecules against oxidative stress.

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.