NADPH 氧化酶在中风康复中的作用

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-08-30 DOI:10.3390/antiox13091065

Dong-Hee Choi, In-Ae Choi, Jongmin Lee

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引用次数: 0

摘要

中风是导致全球死亡和长期残疾的最主要原因之一。NADPH 氧化酶（NOX）过度产生的活性氧在中风后加剧氧化应激和造成神经元损伤方面起着重要作用。越来越多的证据表明，抑制 NOX 可预防缺血性损伤，NOX 在脑损伤或恢复中的作用取决于中风后的特定阶段。除了通过抑制 NOX 对脑卒中后神经保护的研究外，最近的报道还证明了 NOX 在脑卒中恢复中的作用，这是脑卒中后大脑适应和功能重组的关键过程。因此，在本综述中，我们研究了 NOX 在中风恢复中的作用，目的是将临床前研究结果与潜在的治疗策略相结合，以改善中风恢复。

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Role of NADPH Oxidases in Stroke Recovery

Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that NOX inhibition prevents ischemic injury and that the role of NOX in brain damage or recovery depends on specific post-stroke phases. In addition to studies on post-stroke neuroprotection by NOX inhibition, recent reports have also demonstrated the role of NOX in stroke recovery, a critical process for brain adaptation and functional reorganization after a stroke. Therefore, in this review, we investigated the role of NOX in stroke recovery with the aim of integrating preclinical findings into potential therapeutic strategies to improve stroke recovery.

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.