从橄榄油副产品 Alperujo 中提取的果胶多酚复合物的健康促进特性:抗氧化、抗增殖和抗炎活性

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alejandra Bermúdez-Oria, María Luisa Castejón, Fátima Rubio-Senent, Guillermo Rodríguez-Gutiérrez, Juan Fernández-Bolaños
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引用次数: 0

摘要

这项研究探讨了从橄榄油生产的副产品 alperujo 中提取的果胶-多酚复合物的健康促进特性。本研究调查了提取物的化学成分和抗氧化活性,发现其在体外具有很高的抗氧化活性。在结肠癌细胞(Caco-2)上进行的细胞活力测定表明,萃取物对细胞增殖有抑制作用。然而,这些提取物并不影响已分化的 Caco-2 细胞的活力,这表明它们具有选择性的抗增殖作用。此外,提取物还能减少 LPS 刺激的小鼠腹腔巨噬细胞内活性氧(ROS)和亚硝酸盐(NO)的产生。此外,果胶提取物还能降低巨噬细胞中促炎细胞因子 TNF-α、IL-1β 和 IL-6 的分泌,从而显示出抗炎作用。这些发现凸显了果胶-多酚复合物作为功能性成分的潜力,它具有抗氧化、抗增殖和抗炎特性,对健康大有裨益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities
This research explores the health-promoting properties of the pectin–polyphenol complex extracted from alperujo, a by-product of olive oil production. This study investigates the chemical composition and antioxidant activity of the extracts, revealing their high antioxidant activity in vitro. Cell viability assays conducted on colon carcinoma cells (Caco-2) demonstrate the inhibitory effect of the extracts on cell proliferation. However, the extracts do not affect the viability of differentiated Caco-2 cells, suggesting a selective antiproliferative action. Additionally, the extracts reduce intracellular reactive oxygen species (ROS) and nitrite (NO) production in LPS-stimulated murine peritoneal macrophages. Furthermore, the extracts exhibit anti-inflammatory effects by downregulating the secretion of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in these macrophages. These findings highlight the potential of pectin–polyphenol complexes as functional ingredients with significant health benefits, demonstrating antioxidant, antiproliferative, and anti-inflammatory properties.
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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