{"title":"用于高灵敏无标记生物传感的新型双栅负电容 TFET","authors":"Ravindra Kumar Maurya, Radhe Gobinda Debnath, Ajeet Kumar Yadav, Brinda Bhowmick","doi":"10.1088/1361-6641/ad6eb0","DOIUrl":null,"url":null,"abstract":"The negative capacitance (NC) tunnel FET (NCTFET) emerges as a viable choice for the development of highly sensitive biosensors. A dual-gate (DG) structure and n+ doped pocket within the NCTFET is introduced in this study to boost biosensor performance and sensitivity. This research offers a comprehensive and comparative analysis of two biosensor designs: the DG-NCTFET and the n+ pocket-doped DG-NCTFET. Both biosensors feature nanogaps on either side of the fixed dielectric, augmenting their biomolecule capture areas. Sensitivity assessments are conducted considering charged and neutral biomolecules with a range of dielectric constants (<italic toggle=\"yes\">k</italic>). The n+ pocket DG-NCTFET exhibits an <italic toggle=\"yes\">I</italic><sub>ON</sub> sensitivity roughly 20 times greater than that of the sensor without a pocket (3.5 × 10<sup>6</sup> for n+ pocket DG-NCTFET and 1.8 × 10<sup>5</sup> for DG-NCTFET), primarily because it conducts current in both vertical and lateral directions. Furthermore, for fully filled nanocavity with neutral biomolecules, the maximum <italic toggle=\"yes\">I</italic><sub>ON</sub>/<italic toggle=\"yes\">I</italic><sub>OFF</sub> sensitivities attained are 1.2 × 10<sup>5</sup> and 2.8 × 10<sup>4</sup> for the n+ pocket DG-NCTFET and conventional DG-NCTFET, respectively. Moreover, this research delves into the impact of steric hindrance and the irregular placement of probes, aiming to grasp the non-ideal traits exhibited by the sensors. Significantly, sensitivity experiences a minimal increase of approximately 6<bold>%–</bold>11% when the fill factor escalates from 40% to 66%. In order to set a standard of comparison, the proposed biosensors are benchmarked against existing literature in terms of sensitivity, affirming their efficacy. The findings indicate that the proposed biosensors represent a promising alternative for detecting a wide range of both charged and neutral biomolecules.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel dual-gate negative capacitance TFET for highly sensitive label free biosensing\",\"authors\":\"Ravindra Kumar Maurya, Radhe Gobinda Debnath, Ajeet Kumar Yadav, Brinda Bhowmick\",\"doi\":\"10.1088/1361-6641/ad6eb0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The negative capacitance (NC) tunnel FET (NCTFET) emerges as a viable choice for the development of highly sensitive biosensors. A dual-gate (DG) structure and n+ doped pocket within the NCTFET is introduced in this study to boost biosensor performance and sensitivity. This research offers a comprehensive and comparative analysis of two biosensor designs: the DG-NCTFET and the n+ pocket-doped DG-NCTFET. Both biosensors feature nanogaps on either side of the fixed dielectric, augmenting their biomolecule capture areas. Sensitivity assessments are conducted considering charged and neutral biomolecules with a range of dielectric constants (<italic toggle=\\\"yes\\\">k</italic>). The n+ pocket DG-NCTFET exhibits an <italic toggle=\\\"yes\\\">I</italic><sub>ON</sub> sensitivity roughly 20 times greater than that of the sensor without a pocket (3.5 × 10<sup>6</sup> for n+ pocket DG-NCTFET and 1.8 × 10<sup>5</sup> for DG-NCTFET), primarily because it conducts current in both vertical and lateral directions. Furthermore, for fully filled nanocavity with neutral biomolecules, the maximum <italic toggle=\\\"yes\\\">I</italic><sub>ON</sub>/<italic toggle=\\\"yes\\\">I</italic><sub>OFF</sub> sensitivities attained are 1.2 × 10<sup>5</sup> and 2.8 × 10<sup>4</sup> for the n+ pocket DG-NCTFET and conventional DG-NCTFET, respectively. Moreover, this research delves into the impact of steric hindrance and the irregular placement of probes, aiming to grasp the non-ideal traits exhibited by the sensors. Significantly, sensitivity experiences a minimal increase of approximately 6<bold>%–</bold>11% when the fill factor escalates from 40% to 66%. In order to set a standard of comparison, the proposed biosensors are benchmarked against existing literature in terms of sensitivity, affirming their efficacy. The findings indicate that the proposed biosensors represent a promising alternative for detecting a wide range of both charged and neutral biomolecules.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6641/ad6eb0\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6641/ad6eb0","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A novel dual-gate negative capacitance TFET for highly sensitive label free biosensing
The negative capacitance (NC) tunnel FET (NCTFET) emerges as a viable choice for the development of highly sensitive biosensors. A dual-gate (DG) structure and n+ doped pocket within the NCTFET is introduced in this study to boost biosensor performance and sensitivity. This research offers a comprehensive and comparative analysis of two biosensor designs: the DG-NCTFET and the n+ pocket-doped DG-NCTFET. Both biosensors feature nanogaps on either side of the fixed dielectric, augmenting their biomolecule capture areas. Sensitivity assessments are conducted considering charged and neutral biomolecules with a range of dielectric constants (k). The n+ pocket DG-NCTFET exhibits an ION sensitivity roughly 20 times greater than that of the sensor without a pocket (3.5 × 106 for n+ pocket DG-NCTFET and 1.8 × 105 for DG-NCTFET), primarily because it conducts current in both vertical and lateral directions. Furthermore, for fully filled nanocavity with neutral biomolecules, the maximum ION/IOFF sensitivities attained are 1.2 × 105 and 2.8 × 104 for the n+ pocket DG-NCTFET and conventional DG-NCTFET, respectively. Moreover, this research delves into the impact of steric hindrance and the irregular placement of probes, aiming to grasp the non-ideal traits exhibited by the sensors. Significantly, sensitivity experiences a minimal increase of approximately 6%–11% when the fill factor escalates from 40% to 66%. In order to set a standard of comparison, the proposed biosensors are benchmarked against existing literature in terms of sensitivity, affirming their efficacy. The findings indicate that the proposed biosensors represent a promising alternative for detecting a wide range of both charged and neutral biomolecules.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.