{"title":"膳食中天然叶酸和合成叶酸与生物衰老的共同暴露模式:2003-2018 年 NHANES 调查发现","authors":"Jia Zhang, Xuan-Yang Wang, Shuo Yang, Xun Xie, Si-Jia Pan, Xiao-Qing Xu, Ying Li","doi":"10.1039/d4fo01241k","DOIUrl":null,"url":null,"abstract":"Background: The mandatory folic acid fortification program in the United States has inevitably exposed most Americans to both natural folate and synthetic folic acid. We aim to examine the association of dietary folate co-exposure patterns with biological aging indicators. Methods: A total of 18889 participants were enrolled from 2003 to 2018. Dietary intake of folate from diverse sources was evaluated by 24-hour dietary recall. Biological aging indicators were developed based on age-related clinical indilcators, including phenotypic age (PA), Klemera-Doubal method (KDM), homeostatic dysregulation (HD), and allostatic load (AL). The unsupervised K-means clustering method, logistic regression model, and restricted cubic spline (RCS) regression model were used to explore the relationship of natural folate and synthetic folic acid co-exposure with biological aging indicators. Results: The results indicated that higher intake of total folate, dietary folate, and food natural folate was associated with lower PA [OR=0.75(0.64,0.88); OR=0.79(0.70,0.90); OR=0.65(0.57,0.75)], KDM [OR=0.63(0.53,0.75); OR=0.80(0.65,0.98); OR=0.62(0.49,0.77)], HD [OR=0.69(0.56,0.84); OR=0.78(0.67,0.92); OR=0.78(0.68,0.90)], and AL [OR=0.69(0.58,0.82); OR=0.73(0.63,0.85); OR=0.74(0.62,0.90)], consistently. Four co-exposure patterns were generated based on the intake of folate from diverse sources, as follows: \"low folate exposure group\" to cluster 1, \" dietary folate exposure group\" to cluster 2, \"mixed source high folate exposure group\" to cluster 3, and \"mixed source excessive folate exposure group\" to cluster 4. Compared with cluster 1, participants in cluster 2 are associated with lower biological age indicators (ORPA = 0.82[0.72, 0.93]; ORKDM = 0.58[0.47, 0.70]; ORHD = 0.85[0.75, 0.97]; ORAL = 0.87[0.77, 0.98]), while participants in cluster 3 and cluster 4 are not. Conclusion: For individuals subject to folic acid fortification programs, a higher intake of dietary folate, especially natural folate, coupled with a lower consumption of folic acid supplements, was found to be associated with lower biological age indicators.","PeriodicalId":77,"journal":{"name":"Food & Function","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dietary natural folate and synthetic folic acid co-exposure patterns with biological aging: finding from NHANES 2003-2018\",\"authors\":\"Jia Zhang, Xuan-Yang Wang, Shuo Yang, Xun Xie, Si-Jia Pan, Xiao-Qing Xu, Ying Li\",\"doi\":\"10.1039/d4fo01241k\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The mandatory folic acid fortification program in the United States has inevitably exposed most Americans to both natural folate and synthetic folic acid. We aim to examine the association of dietary folate co-exposure patterns with biological aging indicators. Methods: A total of 18889 participants were enrolled from 2003 to 2018. Dietary intake of folate from diverse sources was evaluated by 24-hour dietary recall. Biological aging indicators were developed based on age-related clinical indilcators, including phenotypic age (PA), Klemera-Doubal method (KDM), homeostatic dysregulation (HD), and allostatic load (AL). The unsupervised K-means clustering method, logistic regression model, and restricted cubic spline (RCS) regression model were used to explore the relationship of natural folate and synthetic folic acid co-exposure with biological aging indicators. Results: The results indicated that higher intake of total folate, dietary folate, and food natural folate was associated with lower PA [OR=0.75(0.64,0.88); OR=0.79(0.70,0.90); OR=0.65(0.57,0.75)], KDM [OR=0.63(0.53,0.75); OR=0.80(0.65,0.98); OR=0.62(0.49,0.77)], HD [OR=0.69(0.56,0.84); OR=0.78(0.67,0.92); OR=0.78(0.68,0.90)], and AL [OR=0.69(0.58,0.82); OR=0.73(0.63,0.85); OR=0.74(0.62,0.90)], consistently. Four co-exposure patterns were generated based on the intake of folate from diverse sources, as follows: \\\"low folate exposure group\\\" to cluster 1, \\\" dietary folate exposure group\\\" to cluster 2, \\\"mixed source high folate exposure group\\\" to cluster 3, and \\\"mixed source excessive folate exposure group\\\" to cluster 4. Compared with cluster 1, participants in cluster 2 are associated with lower biological age indicators (ORPA = 0.82[0.72, 0.93]; ORKDM = 0.58[0.47, 0.70]; ORHD = 0.85[0.75, 0.97]; ORAL = 0.87[0.77, 0.98]), while participants in cluster 3 and cluster 4 are not. Conclusion: For individuals subject to folic acid fortification programs, a higher intake of dietary folate, especially natural folate, coupled with a lower consumption of folic acid supplements, was found to be associated with lower biological age indicators.\",\"PeriodicalId\":77,\"journal\":{\"name\":\"Food & Function\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food & Function\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1039/d4fo01241k\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food & Function","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1039/d4fo01241k","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Dietary natural folate and synthetic folic acid co-exposure patterns with biological aging: finding from NHANES 2003-2018
Background: The mandatory folic acid fortification program in the United States has inevitably exposed most Americans to both natural folate and synthetic folic acid. We aim to examine the association of dietary folate co-exposure patterns with biological aging indicators. Methods: A total of 18889 participants were enrolled from 2003 to 2018. Dietary intake of folate from diverse sources was evaluated by 24-hour dietary recall. Biological aging indicators were developed based on age-related clinical indilcators, including phenotypic age (PA), Klemera-Doubal method (KDM), homeostatic dysregulation (HD), and allostatic load (AL). The unsupervised K-means clustering method, logistic regression model, and restricted cubic spline (RCS) regression model were used to explore the relationship of natural folate and synthetic folic acid co-exposure with biological aging indicators. Results: The results indicated that higher intake of total folate, dietary folate, and food natural folate was associated with lower PA [OR=0.75(0.64,0.88); OR=0.79(0.70,0.90); OR=0.65(0.57,0.75)], KDM [OR=0.63(0.53,0.75); OR=0.80(0.65,0.98); OR=0.62(0.49,0.77)], HD [OR=0.69(0.56,0.84); OR=0.78(0.67,0.92); OR=0.78(0.68,0.90)], and AL [OR=0.69(0.58,0.82); OR=0.73(0.63,0.85); OR=0.74(0.62,0.90)], consistently. Four co-exposure patterns were generated based on the intake of folate from diverse sources, as follows: "low folate exposure group" to cluster 1, " dietary folate exposure group" to cluster 2, "mixed source high folate exposure group" to cluster 3, and "mixed source excessive folate exposure group" to cluster 4. Compared with cluster 1, participants in cluster 2 are associated with lower biological age indicators (ORPA = 0.82[0.72, 0.93]; ORKDM = 0.58[0.47, 0.70]; ORHD = 0.85[0.75, 0.97]; ORAL = 0.87[0.77, 0.98]), while participants in cluster 3 and cluster 4 are not. Conclusion: For individuals subject to folic acid fortification programs, a higher intake of dietary folate, especially natural folate, coupled with a lower consumption of folic acid supplements, was found to be associated with lower biological age indicators.
期刊介绍:
Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.