部分药用植物的分析特性、抗氧化、抗病毒和抗菌潜力

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Natural Product Communications Pub Date : 2024-09-07 DOI:10.1177/1934578x241274986

Faiza Nazir, Shah Nawaz-ur-Rehman, Sumayya Khadim, Sania Amber, Fuad Ameen, Naveed Ahmad, Srimathi Priya Lakshminarayanan, Munawar Iqbal

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引用次数: 0

摘要

目标/背景：由于对现有抗菌药物产生抗药性或新型微生物对人类造成致命后果，微生物的感染后果多种多样。目前正在进行研究以控制各种病毒性疾病；因此，可以对具有多种生物特性的药用植物和草本植物的抗病毒潜力进行评估。方法：研究了 NADES 和 Senna alexandrina（S. alexandrina）、Peganum harmala（P. harmala）和 Citrullus colocynthis（C. colocynthis）的水提取物对感染棉花卷叶木兰病毒的烟草的抗病毒潜力。结果抗病毒试验结果表明，P. harmala 的水提取物和 NADES 提取物均不具有抗病毒活性。然而，与 NADES 提取物相比，S. alexandrina 和 C. colocynthis 的水提取物成功抑制了棉花卷叶木兰病毒，使植物得以存活。高压液相色谱（HPLC）和傅立叶变换红外光谱（FTIR）分析表明，与 NADES 提取物相比，S. alexandrina、C. colocynthis 和 P. harmala 水提取物中的酚类和黄酮类化合物含量更高。此外，与其他萃取物相比，害羞草的水萃取物和 NADES 萃取物对金黄色葡萄球菌具有更强的抗氧化和抗菌活性，而 C. colocynthis 的 NADES 萃取物对大肠杆菌菌株具有更强的抗菌活性。结论因此，这些结果表明，番泻叶和壳斗菜具有很强的抗病毒活性，表明这些植物可作为治疗病毒感染的药物。

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Analytical Characterization, Antioxidant, Antiviral and Antimicrobial Potential of Selected Medicinal Plants

Objectives/background: The infectious consequences of microorganisms are varied due to resistance to existing antimicrobial drugs or new types of microbes causing lethal consequences for humans. Investigation are being performed to control different viral diseases; therefore; medicinal and herbal plants which have a variety of biological properties, can be evaluated for their anti-viral potential. Methods: The antiviral potential of NADES and water extracts of Senna alexandrina ( S. alexandrina), Peganum harmala ( P. harmala) and Citrullus colocynthis ( C. colocynthis) on Nicotiana benthamiana infected with Cotton Leaf Curl Multan virus were investigated. Results: The results of the antiviral assay revealed that both water and NADES extracts of P. harmala could not exhibit antiviral activity. However, water extracts of S. alexandrina and C. colocynthis successfully inhibited the Cotton Leaf Curl Multan virus , allowing the plant to survive compared to their NADES extracts. High-pressure liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR) analyses showed higher phenolic and flavonoid content in the water extracts of S. alexandrina, C. colocynthis and P. harmala compared to the NADES extracts. Additionally, both water and NADES extracts of P. harmala showed greater antioxidant and antimicrobial activity against S.aureus in comparison to other extracts, while the NADES extract of C. colocynthis demonstrated higher antimicrobial activity against E.coli strains. Conclusions: Therefore, these results demonstrated that Senna Alexandrina and Citrullus Colocynthis exhibited potent antiviral activity, suggesting that these plants could be therapeutic agent for treating viral infections.

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来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.