{"title":"Phloroglucinol 衍生物对灰葡萄孢菌和果糖单胞菌的抗真菌活性","authors":"Chen-Xin Jing, Yong-Mei Hu, Ya-Rui Jin, An-Ping Li, Rui Wang, Shao-Yong Zhang, Zhengrong Wu, Xiao-Yu Yan, Zhi-Jun Zhang, Hong-Jie Liang, Jun-Xia An, Ying-Qian Liu","doi":"10.1021/acs.jafc.4c05968","DOIUrl":null,"url":null,"abstract":"Naturally derived compounds show promise as treatments for microbial infections. Polyphenols, abundantly found in various plants, fruits, and vegetables, are noted for their physiological benefits including antimicrobial effects. This study introduced a new set of acylated phloroglucinol derivatives, synthesized and tested for their antifungal activity in vitro against seven different pathogenic fungi. The standout compound, 3-methyl-1-(2,4,6-trihydroxyphenyl) butan-1-one (<b>2b</b>), exhibited remarkable fungicidal strength, with EC<sub>50</sub> values of 1.39 μg/mL against <i>Botrytis cinerea</i> and 1.18 μg/mL against <i>Monilinia fructicola</i>, outperforming previously screened phenolic compounds. When tested in vivo, <b>2b</b> demonstrated effective antifungal properties, with cure rates of 76.26% for brown rot and 83.35% for gray mold at a concentration of 200 μg/mL, rivaling the commercial fungicide Pyrimethanil in its efficacy against <i>B. cinerea</i>. Preliminary research suggests that <b>2b’</b>s antifungal mechanism may involve the disruption of spore germination, damage to the fungal cell membrane, and leakage of cellular contents. These results indicate that compound <b>2b</b> has excellent fungicidal properties against <i>B. cinerea</i> and holds potential as a treatment for gray mold.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"3 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antifungal Activity of Phloroglucinol Derivatives against Botrytis cinerea and Monilinia fructicola\",\"authors\":\"Chen-Xin Jing, Yong-Mei Hu, Ya-Rui Jin, An-Ping Li, Rui Wang, Shao-Yong Zhang, Zhengrong Wu, Xiao-Yu Yan, Zhi-Jun Zhang, Hong-Jie Liang, Jun-Xia An, Ying-Qian Liu\",\"doi\":\"10.1021/acs.jafc.4c05968\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Naturally derived compounds show promise as treatments for microbial infections. Polyphenols, abundantly found in various plants, fruits, and vegetables, are noted for their physiological benefits including antimicrobial effects. This study introduced a new set of acylated phloroglucinol derivatives, synthesized and tested for their antifungal activity in vitro against seven different pathogenic fungi. The standout compound, 3-methyl-1-(2,4,6-trihydroxyphenyl) butan-1-one (<b>2b</b>), exhibited remarkable fungicidal strength, with EC<sub>50</sub> values of 1.39 μg/mL against <i>Botrytis cinerea</i> and 1.18 μg/mL against <i>Monilinia fructicola</i>, outperforming previously screened phenolic compounds. When tested in vivo, <b>2b</b> demonstrated effective antifungal properties, with cure rates of 76.26% for brown rot and 83.35% for gray mold at a concentration of 200 μg/mL, rivaling the commercial fungicide Pyrimethanil in its efficacy against <i>B. cinerea</i>. Preliminary research suggests that <b>2b’</b>s antifungal mechanism may involve the disruption of spore germination, damage to the fungal cell membrane, and leakage of cellular contents. These results indicate that compound <b>2b</b> has excellent fungicidal properties against <i>B. cinerea</i> and holds potential as a treatment for gray mold.\",\"PeriodicalId\":41,\"journal\":{\"name\":\"Journal of Agricultural and Food Chemistry\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Agricultural and Food Chemistry\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.jafc.4c05968\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1021/acs.jafc.4c05968","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Antifungal Activity of Phloroglucinol Derivatives against Botrytis cinerea and Monilinia fructicola
Naturally derived compounds show promise as treatments for microbial infections. Polyphenols, abundantly found in various plants, fruits, and vegetables, are noted for their physiological benefits including antimicrobial effects. This study introduced a new set of acylated phloroglucinol derivatives, synthesized and tested for their antifungal activity in vitro against seven different pathogenic fungi. The standout compound, 3-methyl-1-(2,4,6-trihydroxyphenyl) butan-1-one (2b), exhibited remarkable fungicidal strength, with EC50 values of 1.39 μg/mL against Botrytis cinerea and 1.18 μg/mL against Monilinia fructicola, outperforming previously screened phenolic compounds. When tested in vivo, 2b demonstrated effective antifungal properties, with cure rates of 76.26% for brown rot and 83.35% for gray mold at a concentration of 200 μg/mL, rivaling the commercial fungicide Pyrimethanil in its efficacy against B. cinerea. Preliminary research suggests that 2b’s antifungal mechanism may involve the disruption of spore germination, damage to the fungal cell membrane, and leakage of cellular contents. These results indicate that compound 2b has excellent fungicidal properties against B. cinerea and holds potential as a treatment for gray mold.
期刊介绍:
The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.