苹果囊泡治疗炎症性肠病的革命性肠道微生物群疗法

IF 4.8 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Letizia Ferroni , Andrea Rubini , Paolo Bargellini , Elena Tremoli , Ilenia Pia Cappucci , Ugo D'Amora , Alfredo Ronca , Giulia Calogero , Paolo Cortellini Panini , Gisella Bettini , Cristiana Piccoli , Giuseppe Rubini , Lucia Sileo , Maria Pia Cavaleri , Luca Lovatti , Barbara Zavan
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引用次数: 0

摘要

炎症性肠病(IBD)是消化系统的慢性炎症,既可影响人类,也可影响狗等家养宠物。尽管进行了广泛的研究,但仍无法找到确切的治疗方法。本研究调查了苹果衍生细胞外囊泡(ADEVs)对犬 IBD 的治疗潜力。从 "金美味 "苹果中分离出的 ADEVs 被口服给患有 IBD 的狗,为期十天。微生物群分析、临床评估、内窥镜检查和超声波成像结果显示,疾病严重程度和治疗后症状明显减轻。结果表明,ADEVs 可调节肠道微生物的生长并与宿主细胞相互作用。尤其是 IgA 和 calprotectine 含量提高到了生理水平,微生物群和肠粘液糖的含量也提高了。这些结果可以解释为,ADEVs 对 IBD 的舒缓作用可能是由于其对肠道菌群和宿主炎症反应的协同调节作用。总之,这些发现为治疗 IBD 提供了一条前景广阔的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.

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来源期刊
Food Bioscience
Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍: Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.
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