{"title":"苹果囊泡治疗炎症性肠病的革命性肠道微生物群疗法","authors":"","doi":"10.1016/j.fbio.2024.105052","DOIUrl":null,"url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212429224014822/pdfft?md5=e16d8c1d392877a663bbe3c3a85ce8bd&pid=1-s2.0-S2212429224014822-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease\",\"authors\":\"\",\"doi\":\"10.1016/j.fbio.2024.105052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.</p></div>\",\"PeriodicalId\":12409,\"journal\":{\"name\":\"Food Bioscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2212429224014822/pdfft?md5=e16d8c1d392877a663bbe3c3a85ce8bd&pid=1-s2.0-S2212429224014822-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212429224014822\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Bioscience","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212429224014822","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.
Food BioscienceBiochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍:
Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.