人源单克隆自身抗体作为脑细胞蛋白型的询问因子。

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI:10.1016/j.tins.2024.08.004
Matthew L Baum, Christopher M Bartley
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引用次数: 0

摘要

神经科学的一个主要目标是确定神经细胞的功能特性并建立模型,因为神经细胞的功能障碍是神经精神疾病的根源。在本文中,我们提出人源单克隆自身抗体(HD-mAbs)能够很好地选择性地靶向和操纵由蛋白质表达(即细胞蛋白型)定义的神经亚群。最近的技术进步使得从神经精神疾病患者身上高效克隆自身抗体成为可能。这些 HD-mAbs 可被引入动物模型,以获得有关神经蛋白型的生物学和病理生物学知识。蛋白质工程学可用于修饰、增强、沉默或赋予原生 HD-mAbs 新的功能特性,从而增强其多功能性。最后,我们讨论了 HD-mAbs 作为神经科学实验研究工具所面临的挑战和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.

A major aim of neuroscience is to identify and model the functional properties of neural cells whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human-derived monoclonal autoantibodies (HD-mAbs) are well positioned to selectively target and manipulate neural subpopulations as defined by their protein expression; that is, cellular proteotypes. Recent technical advances allow for efficient cloning of autoantibodies from neuropsychiatric patients. These HD-mAbs can be introduced into animal models to gain biological and pathobiological insights about neural proteotypes of interest. Protein engineering can be used to modify, enhance, silence, or confer new functional properties to native HD-mAbs, thereby enhancing their versatility. Finally, we discuss the challenges and limitations confronting HD-mAbs as experimental research tools for neuroscience.

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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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