Anantajit Subrahmanya, Kamalini G Ranasinghe, Hardik Kothare, Inez Raharjo, Kwang S Kim, John F Houde, Srikantan S Nagarajan
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引用次数: 0
摘要
过去的研究探讨了声母居中现象,这是一种在语篇持续时间内向假定目标元音的声母靠拢的矫正行为。在本研究中,我们确定了健康老年人对照组中也存在类似的音调居中现象,并研究了这种纠正行为在阿尔茨海默病(AD)中是如何改变的。我们发现,在纠正低于和高于目标音高(中位数)的音高错误时,健康老人的音高居中反应相似。与此相反,老年痴呆症患者对目标音高以下音高错误的纠正幅度大于目标音高以上音高错误的纠正幅度,表现出不对称性。这些研究结果表明,音高居中是人类言语中一种强有力的补偿行为。我们的研究结果还探讨了影响 AD 患者语音的神经退行性过程对音高居中的潜在影响。
Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease.
Past studies have explored formant centering, a corrective behavior of convergence over the duration of an utterance toward the formants of a putative target vowel. In this study, we establish the existence of a similar centering phenomenon for pitch in healthy elderly controls and examine how such corrective behavior is altered in Alzheimer's Disease (AD). We found the pitch centering response in healthy elderly was similar when correcting pitch errors below and above the target (median) pitch. In contrast, patients with AD showed an asymmetry with a larger correction for the pitch errors below the target phonation than above the target phonation. These findings indicate that pitch centering is a robust compensation behavior in human speech. Our findings also explore the potential impacts on pitch centering from neurodegenerative processes impacting speech in AD.
期刊介绍:
Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.