{"title":"年龄越大，mtDNA 变异的遗传性越低。","authors":"Polyxeni Papadea, Nils-Göran Larsson","doi":"10.1038/s43587-024-00701-4","DOIUrl":null,"url":null,"abstract":"A study from Ru, Deng, Chen, Zhang and colleagues investigates how mutations in the mitochondrial genes Nd1 and Nd5 are inherited in mice. The authors report that increased maternal age strengthens purifying selection during postnatal oocyte development, probably through an increase in oocyte protein synthesis.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Older age reduces mtDNA mutation inheritance\",\"authors\":\"Polyxeni Papadea, Nils-Göran Larsson\",\"doi\":\"10.1038/s43587-024-00701-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A study from Ru, Deng, Chen, Zhang and colleagues investigates how mutations in the mitochondrial genes Nd1 and Nd5 are inherited in mice. The authors report that increased maternal age strengthens purifying selection during postnatal oocyte development, probably through an increase in oocyte protein synthesis.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00701-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00701-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
A study from Ru, Deng, Chen, Zhang and colleagues investigates how mutations in the mitochondrial genes Nd1 and Nd5 are inherited in mice. The authors report that increased maternal age strengthens purifying selection during postnatal oocyte development, probably through an increase in oocyte protein synthesis.
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