{"title":"成像单细胞表观遗传景观，研究衰老轨迹。","authors":"","doi":"10.1038/s43587-024-00689-x","DOIUrl":null,"url":null,"abstract":"We developed ‘imaging-based chromatin and epigenetic age’ (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Imaging the epigenetic landscape in single cells to study aging trajectories\",\"authors\":\"\",\"doi\":\"10.1038/s43587-024-00689-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We developed ‘imaging-based chromatin and epigenetic age’ (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00689-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00689-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Imaging the epigenetic landscape in single cells to study aging trajectories
We developed ‘imaging-based chromatin and epigenetic age’ (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.
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