高脂饮食和富含亚麻籽油饮食对肥胖小鼠肺实质的影响

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Camila de Oliveira Ramos, Marcella Ramos Sant'Ana, Giovana Rios Gonçalves, Thaiane da Silva Rios, Susana Castelo Branco Ramos Nakandakari, Beatriz Burger, Luís Gustavo Romani Fernandes, Ricardo de Lima Zollner, Arthur Noin de Oliveira, Rodrigo Catharino Ramos, Adelino Sanchez Ramos da Silva, José Rodrigo Pauli, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Eli Mansour, Dennys Esper Cintra
{"title":"高脂饮食和富含亚麻籽油饮食对肥胖小鼠肺实质的影响","authors":"Camila de Oliveira Ramos,&nbsp;Marcella Ramos Sant'Ana,&nbsp;Giovana Rios Gonçalves,&nbsp;Thaiane da Silva Rios,&nbsp;Susana Castelo Branco Ramos Nakandakari,&nbsp;Beatriz Burger,&nbsp;Luís Gustavo Romani Fernandes,&nbsp;Ricardo de Lima Zollner,&nbsp;Arthur Noin de Oliveira,&nbsp;Rodrigo Catharino Ramos,&nbsp;Adelino Sanchez Ramos da Silva,&nbsp;José Rodrigo Pauli,&nbsp;Leandro Pereira de Moura,&nbsp;Eduardo Rochete Ropelle,&nbsp;Eli Mansour,&nbsp;Dennys Esper Cintra","doi":"10.1002/mnfr.202300050","DOIUrl":null,"url":null,"abstract":"<p>Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 – ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 18","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice\",\"authors\":\"Camila de Oliveira Ramos,&nbsp;Marcella Ramos Sant'Ana,&nbsp;Giovana Rios Gonçalves,&nbsp;Thaiane da Silva Rios,&nbsp;Susana Castelo Branco Ramos Nakandakari,&nbsp;Beatriz Burger,&nbsp;Luís Gustavo Romani Fernandes,&nbsp;Ricardo de Lima Zollner,&nbsp;Arthur Noin de Oliveira,&nbsp;Rodrigo Catharino Ramos,&nbsp;Adelino Sanchez Ramos da Silva,&nbsp;José Rodrigo Pauli,&nbsp;Leandro Pereira de Moura,&nbsp;Eduardo Rochete Ropelle,&nbsp;Eli Mansour,&nbsp;Dennys Esper Cintra\",\"doi\":\"10.1002/mnfr.202300050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 – ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.</p>\",\"PeriodicalId\":212,\"journal\":{\"name\":\"Molecular Nutrition & Food Research\",\"volume\":\"68 18\",\"pages\":\"\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Nutrition & Food Research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202300050\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Nutrition & Food Research","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202300050","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

欧米茄-3(ω3)脂肪酸因其抗炎潜力而受到广泛研究,但有关其在肥胖症肺实质中的作用的证据却很少。我们的目的是研究富含α-亚麻酸(C18:3 - ω3)的亚麻籽油(FS)对肥胖小鼠肺部的影响。用高脂肪饮食(HF)喂养小鼠 8 周以诱发肥胖。随后,这些动物中的一部分又接受了 8 周含有 FS 油的高脂饮食。高脂饮食诱导体重增加和高血糖。与对照组(CT)相比,肺实质显示出完整的脂肪酸谱。在肺实质中,与高频相比,尽管白细胞介素(IL)IL1β和IL18的含量有所减少,但脂肪酸增加了ω3的含量。然而,FS 增加了肺泡间隙,随后出现了 MCP1(单核细胞趋化蛋白-1)阳性细胞浸润,抗炎细胞因子 IL10 也急剧减少。尽管减少了肺部炎症反应,但食用ω3食物与肺实质的脂质分布和组织结构的改变有关,这可能导致肺部并发症的发生。这项研究提醒人们不要滥用ω3补充剂,应谨慎行事。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice

The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice

The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice

Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 – ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信