计算机模拟各种基线阻抗下的低功率和长时间双极射频消融术

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Yao Sun , Xin Zhu , Wenxi Chen , Weihao Weng , Keijiro Nakamura
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引用次数: 0

摘要

与传统的单极射频消融术(RFA)相比,双极射频消融术具有传热更精确、消融效率更高的优点。临床上,心肌基线阻抗(BI)是影响消融效果的重要因素之一。我们旨在通过分析双极射频消融术在不同基线阻抗下的消融效果和心肌阻抗变化,找到合适的消融方案和应对策略。在这项研究中,我们构建了一个三维局部心肌计算机模型用于双极 RFA 模拟,并使用体外实验数据验证其准确性。初始条件设定为四个固定的低功率水平(20 W、25 W、30 W 和 35 W)和六个心肌 BI(91.02 Ω、99.83 Ω、111.03 Ω、119.77 Ω、130.03 Ω 和 135.45 Ω),消融持续时间为 120 秒。在低功率长持续时间(LPLD)消融的情况下,最大 TID(TIDM)下降了 21-32 Ω,具体取决于 BI。在没有发生蒸汽爆裂的情况下,TIDM 随着功率的增加而增加。在相同功率下,不同 BI 的 TIDM 没有显著差异。模拟结果还显示,功率越大,TIDM 的下降幅度越小。这项研究为双极 LPLD RFA 提供了合适的消融时间和阻抗下降范围。在同时考虑有效性和安全性的情况下,25 W、120 秒的组合提供了最佳性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computer simulation of low-power and long-duration bipolar radiofrequency ablation under various baseline impedances

Compared to traditional unipolar radiofrequency ablation (RFA), bipolar RFA offers advantages such as more precise heat transfer and higher ablation efficiency. Clinically, myocardial baseline impedance (BI) is one of the important factors affecting the effectiveness of ablation. We aim at finding suitable ablation protocols and coping strategies by analyzing the ablation effects and myocardial impedance changes of bipolar RFA under different BIs. In this research, a three-dimensional local myocardial computer model was constructed for bipolar RFA simulation, and in vitro experimental data were used to validate accuracy. Four fixed low-power levels (20 W, 25 W, 30 W, and 35 W) and six myocardial BIs (91.02 Ω, 99.83 Ω, 111.03 Ω, 119.77 Ω, 130.03 Ω, and 135.45 Ω) were set as initial conditions, with an ablation duration of 120-s. In the context of low-power and long-duration (LPLD) ablation, the maximum TID (TIDM) decreased by 21–32 Ω, depending on the BI. In cases where steam pop did not occur, TIDM increased with the increase in power. For the same power, there was no significant difference in TIDM for the range of BIs. In cases where steam pop occurred, for every 1 Ω increase in BI, TIDM increased by 0.34–0.41 Ω. The simulation results also showed that using a higher power resulted in a smaller decrease in TIDM. This study provided appropriate ablation times and impedance decrease ranges for bipolar LPLD RFA. The combination of 25 W for 120-s offered optimal performance when considering effectiveness and safety simultaneously.

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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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