从突触到感觉：circTulp4 的作用。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI:10.1016/j.tins.2024.08.005

Juli Wang, Irina Voineagu

引用次数: 0

摘要

Giusti 及其同事最近的研究表明，circTulp4 可调节兴奋性突触强度。敲除 circTulp4 会破坏小鼠的兴奋-抑制（E/I）平衡，导致对厌恶刺激的超敏反应。这些观察结果更新了我们对环状（circ）RNA在神经系统中的功能及其在神经发育和神经精神疾病中的潜在影响的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From synapse to sensation: the role of circTulp4.

Recent work by Giusti and colleagues showed that circTulp4 modulates excitatory synaptic strength. Knocking down circTulp4 disrupts the excitation-inhibition (E/I) balance in mice and leads to hypersensitivity toward aversive stimuli. These observations update our appreciation of the functions of circular (circ)RNA in the nervous system and their potential implication in neurodevelopmental and neuropsychiatric disorders.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.