正念调节对吸烟者线索诱发渴求神经指数的急性影响

IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL
Ming Zheng , Tiantian Hong , Hui Zhou , Eric L. Garland , Yuzheng Hu
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引用次数: 0

摘要

正念在缓解香烟渴求方面的潜力备受关注;然而,人们对正念功效的神经机制仍缺乏足够的了解。本研究(N=46,均为男性)旨在考察正念策略对调节线索诱发的渴求和相关大脑活动的影响。23名吸烟者与23名非吸烟者进行了比较,前者每天吸烟10支以上,至少已吸食2年。在一项调节渴求的任务中,参与者被要求在吸烟线索暴露时练习正念,或在完成fMRI扫描时被动地查看吸烟线索。2(条件:正念-卷烟和观察-卷烟)×2(阶段:整个吸烟线索暴露期的早期、晚期)重复测量方差分析显示,条件和阶段之间的渴求得分存在显著交互作用,表明正念策略抑制了晚期阶段的渴求。此外,在吸烟者组中,fMRI 分析显示,在涉及奖赏、情绪和知觉的几个大脑网络中,正念条件及其与时间的交互作用具有显著的主效应。具体来说,在正念状态下,双侧脑岛、腹侧纹状体和杏仁核的激活较低,而右侧眶额皮层的激活反映了渴求变化的策略-时间交互效应。这项研究揭示了正念、吸烟线索诱发的渴求和神经活动之间的动态相互作用,为正念如何有效调节香烟渴求提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The acute effect of mindfulness-based regulation on neural indices of cue-induced craving in smokers

Mindfulness has garnered attention for its potential in alleviating cigarette cravings; however, the neural mechanisms underlying its efficacy remain inadequately understood. This study (N=46, all men) aims to examine the impact of a mindfulness strategy on regulating cue-induced craving and associated brain activity. Twenty-three smokers, consuming over 10 cigarettes daily for at least 2 years, were compared to twenty-three non-smokers. During a regulation of craving task, participants were asked to practice mindfulness during smoking cue-exposure or passively view smoking cues while fMRI scans were completed. A 2 (condition: mindfulness-cigarette and look-cigarette) × 2 (phase: early, late of whole smoking cue-exposure period) repeated measures ANOVA showed a significant interaction of the craving scores between condition and phase, indicating that the mindfulness strategy dampened late-phase craving. Additionally, within the smoker group, the fMRI analyses revealed a significant main effect of mindfulness condition and its interaction with time in several brain networks involving reward, emotion, and interoception. Specifically, the bilateral insula, ventral striatum, and amygdala showed lower activation in the mindfulness condition, whereas the activation of right orbitofrontal cortex mirrored the strategy-time interaction effect of the craving change. This study illuminates the dynamic interplay between mindfulness, smoking cue-induced craving, and neural activity, offering insights into how mindfulness may effectively regulate cigarette cravings.

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来源期刊
Addictive behaviors
Addictive behaviors 医学-药物滥用
CiteScore
8.40
自引率
4.50%
发文量
283
审稿时长
46 days
期刊介绍: Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.
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