Victor T.T. Chan , An Ran Ran , Siegfried K. Wagner , Herbert Y.H. Hui , Xiaoyan Hu , Ho Ko , Sharon Fekrat , Yaxing Wang , Cecilia S. Lee , Alvin L. Young , Clement C. Tham , Yih Chung Tham , Pearse A. Keane , Dan Milea , Christopher Chen , Tien Yin Wong , Vincent C.T. Mok , Carol Y. Cheung
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Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise. Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology.
Given the paradigm shift brought by advances in artificial intelligence and the emergence of disease-modifying therapies, this article aims to summarize and review the current literature to highlight 8 trends in an evolving landscape regarding the role and potential value of retinal imaging in AD screening.
期刊介绍：
Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists.
The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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