系统性红斑狼疮事件队列中诊断时间分类标准的敏感性:一项基于挪威人口的研究。

IF 5.1 2区 医学 Q1 RHEUMATOLOGY
Hilde Haukeland, Sigrid Reppe Moe, Cathrine Brunborg, Antonela Botea, Nenad Damjanic, Gro Årthun Wivestad, Heidi Kverneggen Øvreås, Thea Bjerkestrand Bøe, Anniken Orre, Garen Torhild, Helga Sanner, Karoline Lerang, Øyvind Molberg
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引用次数: 0

摘要

目的比较欧洲风湿病学协会联盟/美国风湿病学会(EULAR/ACR)2019 年分类标准与 1997 年 ACR 系统性红斑狼疮(SLE)标准对挪威东南部(290 万居民)推测完整的基于人口的 Nor-SLE 队列中的系统性红斑狼疮病例的敏感性:对 2000 年至 2017 年期间被编码为系统性红斑狼疮的所有病例进行逐一审查。经专家临床评估确诊为系统性红斑狼疮的病例被纳入Nor-SLE队列。记录了核心临床数据,并根据 2019 EULAR/ACR 和 1997 ACR 标准对病例进行了分类。结果:我们纳入了 737 例系统性红斑狼疮病例(701 例成人,36 例青少年)。在诊断时,2019 EULAR/ACR 标准比 1997 ACR 标准对成人更敏感(91.6% 对 77.3%;pConclusion:这项基于人群的研究结果表明,2019 EULAR/ACR 标准与 1997 ACR 标准相比,在诊断系统性红斑狼疮时有 92% 的患者符合标准,这表明 2019 EULAR/ACR 标准将实现其目标,即捕捉更多的早期系统性红斑狼疮病例进行临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway.

Objectives: To compare the sensitivity of 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) classification criteria against 1997 ACR criteria for systemic lupus erythematosus (SLE), for incident SLE cases in the presumably complete population-based Nor-SLE cohort from Southeast Norway (2.9 million inhabitants).

Methods: All cases International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coded as SLE during 2000-2017 were individually reviewed. Those with a confirmed SLE diagnosis by expert clinical assessment were included in the Nor-SLE cohort. Core clinical data were recorded, and the cases were classified according to 2019 EULAR/ACR and 1997 ACR criteria. Juvenile SLE was defined as <16 years at diagnosis and adult SLE was defined as ≥16 years at diagnosis.

Results: We included 737 incident SLE cases (701 adults, 36 juveniles). At diagnosis, 2019 EULAR/ACR criteria were more sensitive than 1997 ACR criteria for adults (91.6% vs 77.3%; p<0.001), but not for juveniles (97.2% vs 88.9%). The 2019 EULAR/ACR counts at diagnosis differed by age group and ethnicity, being higher in young cases and those originating from Asia. From time of diagnosis to study end the fulfilment rate of 2019 EULAR/ACR criteria for the adult cohort increased from 92.5% and 86.5% to 94.6% and 91.0%, respectively, for females and males (mean disease duration of 7.5 years).

Conclusion: Showing 92% criteria fulfilment already at time of SLE diagnosis by 2019 EULAR/ACR criteria versus 77% by 1997 ACR criteria, the results from this population-based study suggest that the 2019 EULAR/ACR criteria will achieve its goal of capturing more early-SLE cases for clinical trials.

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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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