探索女性特有的生殖因素对表型衰老的影响以及生命中必不可少的 8.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Xin Zheng, Yue Chen, Shi-Qi Lin, Chen-Ning Liu, Tong Liu, Chen-An Liu, Zi-Wen Wang, Xiao-Yue Liu, Jin-Yu Shi, Zhao-Ting Bu, Hai-Lun Xie, He-Yang Zhang, Hong Zhao, Shu-Qun Li, Xiang-Rui Li, Li Deng, Han-Ping Shi
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引用次数: 0

摘要

背景介绍衰老是一个不可避免的生理过程。加速衰老使成年人更容易罹患慢性疾病,并增加其死亡率。以往的研究已报道了生活方式因素与表型衰老之间的关系。然而,生殖因素等内在因素与表型衰老之间的关系仍不清楚:本研究利用了美国国家健康与营养调查(NHANES)的数据,时间跨度为 1999 年至 2010 年和 2015 年至 2018 年,共涉及 14736 名成年女性。采用随机森林归因法处理最终队列中缺失的协变量值。加权线性回归用于分析女性特定生殖因素与 PhenoAgeAccel 之间的关系。考虑到绝经状态对结果的潜在影响,还对绝经前和绝经后的参与者进行了额外的分析。此外,还采用了生活必备 8 项指标(LE8)来研究健康生活方式和其他因素对女性特定生殖因素与 PhenoAgeAccel 之间关系的影响。根据显著的交互作用 p 值进行了分层分析:结果:在完全调整模型中,月经初潮推迟和妇科手术与 PhenoAgeAccel 的增加有关,而妊娠史与 PhenoAgeAccel 的减少有关。此外,绝经年龄过早或过晚、首次活产和最后一次活产都会对 PhenoAgeAccel 产生负面影响。妇女特有的生殖因素与 PhenoAgeAccel 之间的关系在绝经前和绝经后妇女之间有所不同。高 LE8 分数会对某些生殖因素(初潮年龄、绝经年龄、首次活产年龄和最后一次活产年龄)与表型年龄加速度之间的关系产生积极影响。分层分析表明,以下变量之间存在明显的交互作用:体重指数与初潮年龄、妊娠史和绝经年龄有关;种族与绝经年龄、首次活产年龄和胎次有关;吸烟状况与服用避孕药和妇科手术有关;高血压与服用避孕药、妊娠史和绝经年龄有关:结论:初潮延迟、妇科手术、绝经年龄、首次活产年龄和最后一次活产年龄过早或过晚与表型老化加速有关。高 LE8 分值可减轻生殖因素对表型衰老的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the impact of women-specific reproductive factors on phenotypic aging and the role of life's essential 8.

Background: Aging is an inevitable biological process. Accelerated aging renders adults more susceptible to chronic diseases and increases their mortality rates. Previous studies have reported the relationship between lifestyle factors and phenotypic aging. However, the relationship between intrinsic factors, such as reproductive factors, and phenotypic aging remains unclear.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES), spanning from 1999 to 2010 and 2015-2018, with 14,736 adult women. Random forest imputation was used to handle missing covariate values in the final cohort. Weighted linear regression was utilized to analyze the relationship between women-specific reproductive factors and PhenoAgeAccel. Considering the potential impact of menopausal status on the results, additional analyses were conducted on premenopausal and postmenopausal participants. Additionally, the Life's Essential 8 (LE8) was used to investigate the impact of healthy lifestyle and other factors on the relationship between women-specific reproductive factors and PhenoAgeAccel. Stratified analyses were conducted based on significant interaction p-values.

Results: In the fully adjusted models, delayed menarche and gynecological surgery were associated with increased PhenoAgeAccel, whereas pregnancy history were associated with a decrease. Additionally, early or late ages of menopause, first live birth, and last live birth can all negatively impact PhenoAgeAccel. The relationship between women-specific reproductive factors and PhenoAgeAccel differs between premenopausal and postmenopausal women. High LE8 scores positively impacted the relationship between certain reproductive factors (age at menarche, age at menopause, age at first live birth, and age at last live birth) and phenotypic age acceleration. Stratified analysis showed significant interactions for the following variables: BMI with age at menarche, pregnancy history, and age at menopause; ethnicity with age at menopause, age at first live birth, and parity; smoking status with use of contraceptive pills and gynecologic surgery; hypertension with use of contraceptive pills, pregnancy history, and age at menopause.

Conclusion: Delayed menarche, gynecological surgery, and early or late ages of menopause, first live birth, and last live birth are associated with accelerated phenotypic aging. High LE8 score may alleviate the adverse effects of reproductive factors on phenotypic aging.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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