一名接受曲美替尼治疗KRAS突变弥漫性胶质瘤的儿童患者罕见地感染了克氏分枝杆菌。

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI:10.1111/pde.15718

Chenin Ryan, Angel Moore, Matthew Davis, Caitlin Yazel, Shabnam Momtahen, Angela M Ricci, Elizabeth A Talbot, Julianne Mann, Nicole Pace

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引用次数: 0

摘要

有丝分裂原激活的细胞外信号调节激酶抑制剂（MEKi）是治疗小儿低级别胶质瘤患者的一种前景广阔的新疗法，因为低级别胶质瘤患者经常会出现有丝分裂原激活的蛋白激酶（MAP 激酶）通路信号异常的情况。然而，人们对小儿胶质瘤患者的长期疗效和毒性了解有限。本文描述了一名接受曲美替尼治疗的低级别胶质瘤儿科患者出现广泛皮肤感染克氏分枝杆菌的罕见病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A rare cutaneous infection with Mycobacterium chelonae in a pediatric patient treated with trametinib for KRAS-mutated diffuse glioma.

Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi) represent a promising new therapy for pediatric patients with low-grade gliomas, which frequently have abnormal signaling within the mitogen-activated protein kinase (MAP kinase) pathway. However, understanding of long-term efficacy and toxicity is limited in pediatric glioma patients. This article describes a rare presentation of a widespread cutaneous infection with Mycobacterium chelonae in a pediatric patient with a low-grade glioma treated with trametinib.

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.