早期的神经元抑制会形成成人大脑皮层半球间的连接。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI:10.1016/j.tins.2024.08.002

Míriam Javier-Torrent, Antonela Bonafina, Laurent Nguyen

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引用次数: 0

摘要

大脑皮层网络在生命早期的成熟涉及长程轴突连接的重大重组。在最近的一项研究中，Bragg-Gonzalo、Aguilera 等人发现，在小鼠体内，由 S1L4 胼胝体投射神经元发出的半球间连接是通过严格控制同侧突触整合来修剪的，而同侧突触整合依赖于特定中间神经元的早期活动。

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Early neuronal inhibition sculpts adult cortical interhemispheric connectivity.

The maturation of cerebral cortical networks during early life involves a major reorganization of long-range axonal connections. In a recent study, Bragg-Gonzalo, Aguilera, et al. discovered that in mice, the interhemispheric connections sent by S1L4 callosal projection neurons are pruned via the tight control of their ipsilateral synaptic integration, which relies on the early activity of specific interneurons.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.