儿科发病的腮腺组织病理学比成人发病的斯约格伦病更严重。

IF 5.1 2区 医学 Q1 RHEUMATOLOGY
Geertje Elizabeth Legger, Uzma Nakshbandi, Martha S van Ginkel, Silvia C Liefers, Lisette de Wolff, Alja J Stel, Wineke Armbrust, Fred K L Spijkervet, Arjan Vissink, Suzanne Arends, Hendrika Bootsma, Bert van der Vegt, Gwenny M Verstappen, Frans G M Kroese
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引用次数: 0

摘要

研究目的本研究旨在评估儿科发病型斯约格伦病患者(pedSjD)与成人发病型斯约格伦病患者(adSjD)的腮腺组织病理学特征:这项研究在荷兰格罗宁根进行。研究对象包括儿科诊断队列中的 pedSjD 患者(19 人)、成人诊断队列中的 adSjD 患者(32 人)以及参与临床试验并进行了基线腮腺活检的 adSjD 患者(42 人)。腮腺活检组织经(免疫)组织学染色后分析SjD相关组织病理学标记物,并进行组间比较:结果:在 pedSjD 中也观察到了 adSjD 的所有特征性组织病理学特征。pedSjD组和adSjD组在淋巴上皮病变或免疫球蛋白A(IgA)/IgG浆细胞转移方面没有明显差异。然而,与诊断性 adSjD 队列(具有可比的 EULAR Sjögren's 综合征疾病活动指数 (ESSDAI) 总分)相比,pedSjD 显示出更严重的淋巴细胞浸润,表现为更高的病灶得分(p=0.003)、更高的 CD45+ 浸润相对表面积(p=0.041)、更高的 B 和 T 淋巴细胞数量/mm2(分别为 p=0.004 和 p=0.029)、更高的 B/T 淋巴细胞比率(p=0.013)、更高的 CD21+ 滤泡树突状细胞网络数量/mm2(p=0.029)和生殖中心 (GC) 数量/mm2(p=0.002)。与adSjD试验队列相比,pedSjD队列的ESSDAI总分显著更高(p=0.001),但只有B/T淋巴细胞比率和GC/mm2数量显著更高(分别为p=0.023和p=0.018):结论:与adSjD患者相比,pedSjD患者在诊断时表现出更明显的组织病理学特征。值得注意的是,pedSjD 患者的组织病理学特征与 adSjD 临床试验队列中观察到的组织病理学特征更为接近,B 淋巴细胞受累更强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren's disease.

Objectives: The aim of this study was to assess the histopathological features of the parotid glands in patients with paediatric-onset Sjögren's disease (pedSjD) in comparison to patients with adult-onset Sjögren's disease (adSjD).

Methods: This study was performed in Groningen, the Netherlands. Patients with pedSjD from a diagnostic paediatric cohort (n=19), patients with adSjD from a diagnostic adult cohort (n=32) and patients with adSjD who participated in a clinical trial (n=42) with a baseline parotid gland biopsy were included. Parotid gland biopsies were analysed after (immuno)histological staining for SjD-related histopathological markers and compared between groups.

Results: All characteristic histopathological features of adSjD were also observed in pedSjD. There were no significant differences in lymphoepithelial lesions or immunoglobulin A (IgA)/IgG plasma cell shift between the pedSjD and the adSjD cohorts. However, compared with the diagnostic adSjD cohort (with comparable total EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) scores), pedSjD showed more severe lymphocytic infiltration as reflected by a higher focus score (p=0.003), a higher relative surface area of CD45+ infiltrate (p=0.041), higher numbers of B and T lymphocytes/mm2 (p=0.004 and p=0.029, respectively), a higher B/T lymphocyte ratio (p=0.013), higher numbers of CD21+ follicular dendritic cell networks/mm2 (p=0.029) and germinal centres (GC)/mm2 (p=0.002). Compared with the trial adSjD cohort, with significant higher total ESSDAI scores (p=0.001), only the B/T lymphocyte ratio and numbers of GC/mm2 were significantly higher in the pedSjD cohort (p=0.023 and p=0.018, respectively).

Conclusion: Patients with pedSjD exhibit more pronounced histopathological features compared with patients with adSjD at diagnosis. Notably, the histopathology of patients with pedSjD aligns more closely with that observed in an adSjD clinical trial cohort, with even stronger B lymphocyte involvement.

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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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