12 种中成药治疗原发性骨质疏松症的疗效和安全性比较：系统回顾与网络荟萃分析

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Natural Product Communications Pub Date : 2024-08-07 DOI:10.1177/1934578x241271671

Qinglin Peng, Jie Han, Ruiqi Wu, Yukun Wu, Feng Chen, Yu Lai

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引用次数: 0

摘要

目的利用网络荟萃分析阐明不同中药治疗原发性骨质疏松症（POP）的有效性和安全性。材料与方法：我们进行了一项系统综述和网络荟萃分析，以评估中成药（CPM）联合常规西药治疗原发性骨质疏松症的有效性和安全性。自 2004 年 3 月 5 日至 2024 年 3 月 5 日，我们全面检索了 Cochrane Library、VIP、PubMed、Embase、CBM、万方、CNKI 和 Web of Science 等电子数据库。本系统综述仅纳入随机对照试验（RCT）。经过筛选和数据提取后，利用 Cochrane 偏倚风险评估工具对纳入研究的方法学质量进行了评估。使用 Stata 15.1 对数据进行综合。结果：共纳入 44 项研究，涉及 4859 名患者。其中治疗组 2577 例，对照组 2282 例，共使用了 12 种 CPM。青娥丸联合常规治疗可显著提高总有效率[相对风险（RR）=2.57，95% 置信区间（CI）（1.32，5.00）]。在常规治疗的基础上，六味地黄丸可明显提高腰椎[WMD = 0.17, 95% CI (0.05, 0.28)]和股骨颈[WMD = 0.23, 95% CI (0.11, 0.35)]的骨密度（BMD）。此外，胡谷胶囊还能有效降低 VAS 评分[WMD = -2.48，95% CI (-3.85, -1.11)] 。龟龄集显著降低了血清 ALP 浓度[WMD = -15.67，95% CI (-32.73, 1.39)]。在所有研究中，均未发现严重不良反应，大多数研究显示仅有轻微胃肠道反应。结论CPM和常规治疗组合可增强持久性有机污染物的治疗效果；每种CPM都有独特的优势。需要更多高质量的 RCT 研究才能得出结论。在诊所中根据患者的特质量身定制药物。

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Comparison of the Efficacy and Safety of 12 Chinese Patent Medicines for Treating Primary Osteoporosis Patients: A Systematic Review and Network Meta-Analysis

Objective: To elucidate the effectiveness and safety of different traditional Chinese medicines (TCMs) for treating primary osteoporosis (POP) using network meta-analysis. Materials and Methods: We conducted a systematic review and network meta-analysis to assess the efficacy and safety of Chinese patent medicine (CPM) combined with conventional Western medicine for POP treatment. From March 5, 2004, to March 5, 2024, electronic databases such as the Cochrane Library, VIP, PubMed, Embase, CBM, Wanfang, CNKI, and Web of Science were comprehensively searched. Only randomized controlled trials (RCTs) were included in this systematic review. After screening and data extraction, the Cochrane risk of bias evaluation tool was utilized to assess the methodological quality of the included studies. Stata 15.1 was utilized to synthesize the data. Results: In total, 44 studies involving 4859 patients were included. There were 2577 patients in the treatment group and 2282 in the control group, with 12 types of CPMs. Qing'e Pill, in combination with conventional treatment, significantly improved the total effective rate [relative risk (RR) = 2.57, 95% confidence interval (CI) (1.32, 5.00)]. In combination with conventional treatment, Liuwei Dihuang Pill significantly increased the bone mass density (BMD) of the lumbar spine [WMD = 0.17, 95% CI (0.05, 0.28)] and femoral neck [WMD = 0.23, 95% CI (0.11, 0.35)]. Furthermore, Hugu capsules effectively decreased the VAS score [WMD = −2.48, 95% CI (−3.85, −1.11)]. The presence of the genus Gusongbao markedly decreased the serum ALP concentration [WMD = −15.67, 95% CI (−32.73, 1.39)]. In all studies, no serious adverse reactions were noted, with most studies suggesting only mild gastrointestinal reactions. Conclusions: CPM and conventional treatment combo enhances POP therapy; each CPM offers unique benefits. More high-quality RCTs needed for conclusions. Meds tailored to patient traits in clinics.

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来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.