代谢综合征患者的膳食烟酸摄入量及其与全因死亡率和心血管死亡率的关系。

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Yuqing Fu, Cong Xu, Guifu Wu
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引用次数: 0

摘要

背景:代谢综合征患者面临着较高的心血管风险和死亡风险,关于烟酸对心血管的影响及其对代谢综合征预后的影响一直存在争议:暴露:基于 24 小时膳食回忆的膳食烟酸摄入水平:方法:采用卡普兰-梅耶生存曲线比较膳食烟酸摄入量四分位数的生存状况。采用加权 Cox 比例危险模型和限制性立方样条来估计与暴露相关的全因和心血管疾病死亡风险的危险比 (HR) 和 95% 置信区间 (CI):这项队列研究包括 8744 名参与者,在中位 106 个月的随访期间,共记录了 1552 例(17.7%)死亡病例,其中 511 例死于心血管疾病。比较膳食中烟酸摄入量四分位数的 Kaplan-Meier 曲线显示,全因死亡率和心血管疾病死亡率均存在显著差异(对数rank p 结论:膳食中烟酸摄入量四分位数与心血管疾病死亡率之间存在显著差异:这项队列研究的结果表明,膳食中烟酸摄入量越高,代谢综合征人群的心血管和全因死亡率风险就越低。此外,膳食烟酸摄入量与全因和心血管死亡风险之间似乎存在剂量反应关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary niacin Intake and its association with all-cause and cardiovascular mortality rates in individuals with metabolic syndrome.

Background: Individuals with metabolic syndrome face elevated cardiovascular and mortality risks, and there is ongoing debate regarding the cardiovascular effects of niacin and its impact on the prognosis of metabolic syndrome.

Exposure: Levels of dietary niacin intake based on 24-hour dietary recall.

Methods: Kaplan-Meier survival curves were used to compare survival status among quartiles of dietary niacin intake. Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of all-cause and CVD mortality associated with the exposure.

Results: This cohort study included 8,744 participants, and during a median follow-up period of 106 months, 1,552 (17.7%) deaths were recorded, with 511 attributed to cardiovascular disease. Kaplan-Meier curves comparing quartiles of dietary niacin intake showed significant differences in both all-cause and cardiovascular mortality rates (log-rank p < 0.001). In the fully adjusted model, the highest quartile of dietary niacin intake was associated with HRs of 0.68 (95% CI: 0.54, 0.87, P = 0.002) for all-cause mortality and 0.63 (95% CI: 0.39, 0.78, P < 0.001) for cardiovascular mortality.

Conclusion: The results of this cohort study suggest that higher dietary niacin intake is associated with reduced cardiovascular and all-cause mortality risks in the metabolic syndrome population. Furthermore, there appears to be a dose-response relationship between dietary niacin intake and the risks of all-cause and cardiovascular mortality.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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