关于 Occludin 在中风发病机制中作用的文献计量分析。

2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Oxidative Medicine and Cellular Longevity Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI:10.1155/2024/2121733
Zhanylsyn U Urasheva, Gulnar B Kabdrakhmanova, Aigul P Yermagambetova, Aigerim B Utegenova, Nazgul A Seitmaganbetova, Ondassyn M Aliyev, Saulesh S Kurmangaliyeva, Nazym K Kenzhina, Yergen Z Kurmambayev, Alima A Khamidulla
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引用次数: 0

摘要

过去十年间,致力于揭示紧密连接蛋白在缺血性中风相关血脑屏障(BBB)损伤中的复杂作用的研究明显激增。本文献计量学分析探讨了2000-2023年间紧密连接蛋白(一种关键的紧密连接蛋白)研究的广阔前景,揭示了这一中风发病机制关键领域的全球科学贡献、合作和新兴趋势。中国和美国做出了重大贡献,这表明它们在促进我们对紧密连接蛋白的了解方面发挥了重要作用。Occludin 被认为是调节 BBB 完整性的关键蛋白,被证明是一个关键角色,其影响延伸到缺血性中风出血转化的诊断。这项研究发现了一种潜在的生物标记物,为早期诊断提供了希望,并为新型诊断策略铺平了道路。该分析强调了更全面地研究紧密连接蛋白(包括 occludin 和 claudin-5)的必要性,尤其是在急性脑缺血的情况下。哈萨克斯坦独特的医疗保健状况使该地区进一步开展科学研究的呼声更加迫切,强调了开展有针对性的研究以应对特定地区挑战的必要性。本综述不仅描述了闭塞素研究的现状,还指明了未来研究的方向。已确定的知识差距和新趋势为研究人员和决策者提供了路线图,对科学讨论和临床实践都有影响。展望未来,通过本研究获得的洞察力加深对紧密连接蛋白的理解,有可能形成有针对性的治疗干预和诊断策略,最终促进全球中风治疗的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke.

Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins. Occludin, identified as a linchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagic transformation in ischemic stroke. This study identifies occludin as a potential biomarker, offering promise for early diagnosis and paving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tight junction proteins, including occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcare landscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailored investigations to address specific regional challenges. This comprehensive overview not only delineates the current state of occludin research but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide a roadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Moving forward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential to shape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.

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来源期刊
CiteScore
13.20
自引率
0.00%
发文量
1274
审稿时长
3-8 weeks
期刊介绍: Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “bench to bedside” research into clinical strategies.
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