癌症治疗进入新时代:从 "一刀切 "到新一代测序 (NGS) 技术。

IF 2.2 4区 工程技术 Q3 PHARMACOLOGY & PHARMACY
Bioimpacts Pub Date : 2024-01-01 Epub Date: 2023-12-23 DOI:10.34172/bi.2023.29957
Sepideh Parvizpour, Hanieh Beyrampour-Basmenj, Jafar Razmara, Farhad Farhadi, Mohd Shahir Shamsir
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引用次数: 0

摘要

癌症是导致全球死亡的主要原因之一,也是延长预期寿命的最大挑战之一。一刀切 "的医学模式已经让位于根据疾病亚型、临床特征和生物标志物对患者进行分层(分层医学)。下一代测序技术(NGS)在临床肿瘤学中的应用使癌症患者的治疗符合其分子特征成为可能。NGS有望引领向精准医疗(PM)的过渡,即根据每位患者的特征和突变选择合适的治疗方法。在此,我们将重点介绍 NGS 技术如何促进癌症治疗。在这方面,我们首先回顾了精准医疗和 NGS 技术,然后介绍了 NGS 在精准医疗中的革命。接下来,我们将讨论 NGS 在肿瘤学中的作用以及现有的局限性。还综述了用于 NGS 数据分析的可用数据库、生物信息学工具和在线服务器。综述以结束语结束。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies.

Cancer is one of the leading causes of death worldwide and one of the greatest challenges in extending life expectancy. The paradigm of one-size-fits-all medicine has already given way to the stratification of patients by disease subtypes, clinical characteristics, and biomarkers (stratified medicine). The introduction of next-generation sequencing (NGS) in clinical oncology has made it possible to tailor cancer patient therapy to their molecular profiles. NGS is expected to lead the transition to precision medicine (PM), where the right therapeutic approach is chosen for each patient based on their characteristics and mutations. Here, we highlight how the NGS technology facilitates cancer treatment. In this regard, first, precision medicine and NGS technology are reviewed, and then, the NGS revolution in precision medicine is described. In the sequel, the role of NGS in oncology and the existing limitations are discussed. The available databases and bioinformatics tools and online servers used in NGS data analysis are also reviewed. The review ends with concluding remarks.

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来源期刊
Bioimpacts
Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.80
自引率
7.70%
发文量
36
审稿时长
5 weeks
期刊介绍: BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.
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