Christelle Boglione-Kerrien , Audrey Le Bot , David Luque Paz , Marie-Clémence Verdier , Hélène Guegan , Jean-Pierre Gangneux , Eric Bellissant , Florian Lemaitre
{"title":"伏立康唑作为氟康唑耐药尿念珠菌病的替代口服治疗药物。","authors":"Christelle Boglione-Kerrien , Audrey Le Bot , David Luque Paz , Marie-Clémence Verdier , Hélène Guegan , Jean-Pierre Gangneux , Eric Bellissant , Florian Lemaitre","doi":"10.1016/j.idnow.2024.104955","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.</p></div><div><h3>Patients and methods</h3><p>In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.</p></div><div><h3>Results</h3><p>Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included. Urine and plasma voriconazole concentrations, mean 1.7 mg/L (range: 0.3–12.6) and mean 2.0 mg/L (range: 0.1–11.1) respectively, exhibited a strong correlation (R<sup>2</sup> = 0.88). None of the five patients treated for candidiasis experienced clinical or microbiological failure following treatment, with urine concentrations ranging from 0.5 to 2.7 mg/L.</p></div><div><h3>Conclusions</h3><p>The urinary diffusion of voriconazole resulted in drug exposure above the target minimum inhibitory concentration (MIC) in the five patients treated for voriconazole-susceptible <em>Candida</em> strains in urine. Therapeutic drug monitoring may allow optimize <em>in situ</em> concentrations.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104955"},"PeriodicalIF":2.9000,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001222/pdfft?md5=c667b9de3b211c54d14cbdcee0c50a36&pid=1-s2.0-S2666991924001222-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Voriconazole as an alternative oral treatment in fluconazole-resistant urinary candidiasis\",\"authors\":\"Christelle Boglione-Kerrien , Audrey Le Bot , David Luque Paz , Marie-Clémence Verdier , Hélène Guegan , Jean-Pierre Gangneux , Eric Bellissant , Florian Lemaitre\",\"doi\":\"10.1016/j.idnow.2024.104955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.</p></div><div><h3>Patients and methods</h3><p>In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.</p></div><div><h3>Results</h3><p>Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included. Urine and plasma voriconazole concentrations, mean 1.7 mg/L (range: 0.3–12.6) and mean 2.0 mg/L (range: 0.1–11.1) respectively, exhibited a strong correlation (R<sup>2</sup> = 0.88). None of the five patients treated for candidiasis experienced clinical or microbiological failure following treatment, with urine concentrations ranging from 0.5 to 2.7 mg/L.</p></div><div><h3>Conclusions</h3><p>The urinary diffusion of voriconazole resulted in drug exposure above the target minimum inhibitory concentration (MIC) in the five patients treated for voriconazole-susceptible <em>Candida</em> strains in urine. Therapeutic drug monitoring may allow optimize <em>in situ</em> concentrations.</p></div>\",\"PeriodicalId\":13539,\"journal\":{\"name\":\"Infectious diseases now\",\"volume\":\"54 6\",\"pages\":\"Article 104955\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666991924001222/pdfft?md5=c667b9de3b211c54d14cbdcee0c50a36&pid=1-s2.0-S2666991924001222-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases now\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666991924001222\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases now","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666991924001222","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Voriconazole as an alternative oral treatment in fluconazole-resistant urinary candidiasis
Objectives
This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.
Patients and methods
In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.
Results
Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included. Urine and plasma voriconazole concentrations, mean 1.7 mg/L (range: 0.3–12.6) and mean 2.0 mg/L (range: 0.1–11.1) respectively, exhibited a strong correlation (R2 = 0.88). None of the five patients treated for candidiasis experienced clinical or microbiological failure following treatment, with urine concentrations ranging from 0.5 to 2.7 mg/L.
Conclusions
The urinary diffusion of voriconazole resulted in drug exposure above the target minimum inhibitory concentration (MIC) in the five patients treated for voriconazole-susceptible Candida strains in urine. Therapeutic drug monitoring may allow optimize in situ concentrations.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
