芦荟叶提取物降低了脑外伤后 BBB 的渗透性并改善了神经功能:氧化应激的作用

2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Oxidative Medicine and Cellular Longevity Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI:10.1155/2024/5586814
Mohammad Khaksari, Marzieh Shahryari, Alireza Raji-Amirhasani, Zahra Soltani, Bahram Bibak, Zakieh Keshavarzi, Farzaneh Shakeri
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引用次数: 0

摘要

简介由于认识到药用植物的重要性以及缺乏治疗创伤性脑损伤(TBI)的特效药物,本研究旨在评估芦荟水提取物对TBI后氧化应激、血脑屏障(BBB)通透性和神经系统评分的影响:成年雄性大鼠分为五组:假组、创伤性脑损伤组、药物组、低剂量芦荟组(LA)和高剂量芦荟组(HA)。我们使用马尔马罗模型诱导弥漫性创伤性脑损伤,并在创伤性脑损伤后半小时通过腹腔注射芦荟叶水性提取物和载体。对创伤性脑损伤前和创伤性脑损伤后数小时的神经系统结果进行了评估。此外,还测量了创伤后 24 小时的氧化应激因子,并测定了创伤后 5 小时血清和大脑中的埃文斯蓝含量(一种 BBB 通透性指数):结果:LA 和 HA 都能降低创伤后 BBB 通透性的增加,HA 的效果比 LA 更明显。两种剂量的芦荟都能降低脑MDA水平,增加脑TAC,降低血清和脑PC水平。芦荟对脑氧化参数的影响比对血清的影响更显著。HA 还抵消了创伤后 4 小时和 24 小时内创伤性脑损伤对神经功能的影响:本研究表明,芦荟提取物可通过减少氧化因子和增加抗氧化因子来降低 BBB 的通透性,并改善创伤后的神经功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aloe vera Leaf Extract Reduced BBB Permeability and Improved Neurological Results after Traumatic Brain Injury: The Role of Oxidative Stress.

Introduction: Recognizing the importance of medicinal plants and the absence of specific medications for traumatic brain injury (TBI) treatment, this study was conducted to evaluate the effects of an aqueous extract of Aloe vera on oxidative stress, blood-brain barrier (BBB) permeability, and neurological scores following TBI.

Materials and methods: Adult male rats were categorized into five groups: sham, TBI, vehicle, low-dose Aloe vera (LA), and high-dose Aloe vera (HA). We induced diffuse TBI using the Marmaro model and administered the aqueous Aloe vera leaf extract, as well as vehicle, via intraperitoneal injection half an hour after TBI. Neurological outcomes were assessed both before and several hours after TBI. Additionally, oxidative stress factors were measured 24 hr after TBI, and Evans blue content (a BBB permeability index) was determined 5 hr after TBI in both serum and brain.

Results: Both LA and HA reduced the increase in BBB permeability after TBI, with HA having a more pronounced effect than LA. Both Aloe vera doses decreased brain MDA levels, increased brain TAC, and lowered both serum and brain PC levels. The impact of Aloe vera on brain oxidative parameters was more significant than on serum. HA also counteracted the declining effects of TBI on neurological outcomes at 4 and 24 hr post-TBI.

Conclusion: This study suggests that Aloe vera extract may reduce BBB permeability and improve neurological outcomes after TBI by decreasing oxidative factors and increasing antioxidant factors.

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来源期刊
CiteScore
13.20
自引率
0.00%
发文量
1274
审稿时长
3-8 weeks
期刊介绍: Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “bench to bedside” research into clinical strategies.
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