{"title":"芦荟叶提取物降低了脑外伤后 BBB 的渗透性并改善了神经功能:氧化应激的作用","authors":"Mohammad Khaksari, Marzieh Shahryari, Alireza Raji-Amirhasani, Zahra Soltani, Bahram Bibak, Zakieh Keshavarzi, Farzaneh Shakeri","doi":"10.1155/2024/5586814","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Recognizing the importance of medicinal plants and the absence of specific medications for traumatic brain injury (TBI) treatment, this study was conducted to evaluate the effects of an aqueous extract of <i>Aloe vera</i> on oxidative stress, blood-brain barrier (BBB) permeability, and neurological scores following TBI.</p><p><strong>Materials and methods: </strong>Adult male rats were categorized into five groups: sham, TBI, vehicle, low-dose <i>Aloe vera</i> (LA), and high-dose <i>Aloe vera</i> (HA). We induced diffuse TBI using the Marmaro model and administered the aqueous <i>Aloe vera</i> leaf extract, as well as vehicle, via intraperitoneal injection half an hour after TBI. Neurological outcomes were assessed both before and several hours after TBI. Additionally, oxidative stress factors were measured 24 hr after TBI, and Evans blue content (a BBB permeability index) was determined 5 hr after TBI in both serum and brain.</p><p><strong>Results: </strong>Both LA and HA reduced the increase in BBB permeability after TBI, with HA having a more pronounced effect than LA. Both <i>Aloe vera</i> doses decreased brain MDA levels, increased brain TAC, and lowered both serum and brain PC levels. The impact of <i>Aloe vera</i> on brain oxidative parameters was more significant than on serum. HA also counteracted the declining effects of TBI on neurological outcomes at 4 and 24 hr post-TBI.</p><p><strong>Conclusion: </strong>This study suggests that <i>Aloe vera</i> extract may reduce BBB permeability and improve neurological outcomes after TBI by decreasing oxidative factors and increasing antioxidant factors.</p>","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262876/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Aloe vera</i> Leaf Extract Reduced BBB Permeability and Improved Neurological Results after Traumatic Brain Injury: The Role of Oxidative Stress.\",\"authors\":\"Mohammad Khaksari, Marzieh Shahryari, Alireza Raji-Amirhasani, Zahra Soltani, Bahram Bibak, Zakieh Keshavarzi, Farzaneh Shakeri\",\"doi\":\"10.1155/2024/5586814\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Recognizing the importance of medicinal plants and the absence of specific medications for traumatic brain injury (TBI) treatment, this study was conducted to evaluate the effects of an aqueous extract of <i>Aloe vera</i> on oxidative stress, blood-brain barrier (BBB) permeability, and neurological scores following TBI.</p><p><strong>Materials and methods: </strong>Adult male rats were categorized into five groups: sham, TBI, vehicle, low-dose <i>Aloe vera</i> (LA), and high-dose <i>Aloe vera</i> (HA). We induced diffuse TBI using the Marmaro model and administered the aqueous <i>Aloe vera</i> leaf extract, as well as vehicle, via intraperitoneal injection half an hour after TBI. Neurological outcomes were assessed both before and several hours after TBI. Additionally, oxidative stress factors were measured 24 hr after TBI, and Evans blue content (a BBB permeability index) was determined 5 hr after TBI in both serum and brain.</p><p><strong>Results: </strong>Both LA and HA reduced the increase in BBB permeability after TBI, with HA having a more pronounced effect than LA. Both <i>Aloe vera</i> doses decreased brain MDA levels, increased brain TAC, and lowered both serum and brain PC levels. The impact of <i>Aloe vera</i> on brain oxidative parameters was more significant than on serum. HA also counteracted the declining effects of TBI on neurological outcomes at 4 and 24 hr post-TBI.</p><p><strong>Conclusion: </strong>This study suggests that <i>Aloe vera</i> extract may reduce BBB permeability and improve neurological outcomes after TBI by decreasing oxidative factors and increasing antioxidant factors.</p>\",\"PeriodicalId\":19657,\"journal\":{\"name\":\"Oxidative Medicine and Cellular Longevity\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262876/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oxidative Medicine and Cellular Longevity\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/5586814\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxidative Medicine and Cellular Longevity","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1155/2024/5586814","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Aloe vera Leaf Extract Reduced BBB Permeability and Improved Neurological Results after Traumatic Brain Injury: The Role of Oxidative Stress.
Introduction: Recognizing the importance of medicinal plants and the absence of specific medications for traumatic brain injury (TBI) treatment, this study was conducted to evaluate the effects of an aqueous extract of Aloe vera on oxidative stress, blood-brain barrier (BBB) permeability, and neurological scores following TBI.
Materials and methods: Adult male rats were categorized into five groups: sham, TBI, vehicle, low-dose Aloe vera (LA), and high-dose Aloe vera (HA). We induced diffuse TBI using the Marmaro model and administered the aqueous Aloe vera leaf extract, as well as vehicle, via intraperitoneal injection half an hour after TBI. Neurological outcomes were assessed both before and several hours after TBI. Additionally, oxidative stress factors were measured 24 hr after TBI, and Evans blue content (a BBB permeability index) was determined 5 hr after TBI in both serum and brain.
Results: Both LA and HA reduced the increase in BBB permeability after TBI, with HA having a more pronounced effect than LA. Both Aloe vera doses decreased brain MDA levels, increased brain TAC, and lowered both serum and brain PC levels. The impact of Aloe vera on brain oxidative parameters was more significant than on serum. HA also counteracted the declining effects of TBI on neurological outcomes at 4 and 24 hr post-TBI.
Conclusion: This study suggests that Aloe vera extract may reduce BBB permeability and improve neurological outcomes after TBI by decreasing oxidative factors and increasing antioxidant factors.
期刊介绍:
Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “bench to bedside” research into clinical strategies.