{"title":"普洱茶可降低CRD介导的脱发风险向后代的传递","authors":"Shanshan Hu, Jie Wang, Zhiyuan Lin, Bowen Zhang, Liyong Luo, Liang Zeng","doi":"10.1002/fft2.409","DOIUrl":null,"url":null,"abstract":"<p>Circadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu-erh tea, with alleviating effects of CRD-mediated syndrome, can act on the transmission of alopecia risk to offspring is also unproven. Here, we obtained CRD parental mice offspring and found that CRD-mediated alopecia risk can be transmitted to offspring, especially male offspring. Parental consumption of Pu-erh tea, especially in females or both parents, reduced the risk of CRD-mediated alopecia transmitted to offspring by inhibiting subcutaneous fat accumulation (downregulation of Rab18, fat-specific protein 27 (Fsp27), and perilipin 1 (Plin1)), reducing oxidative stress and inflammation in skin tissue (NADPH oxidase 4 (NOX4)/ nuclear factor kappa-B (NF-κB)), balancing androgen and hair growth factor release (hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1)), and restoring hair follicle DNA repair function (upregulation of Ku70, 8-Oxoguanine DNA glycosylase 1 (OGG1), and Rad51). Transcriptomic analysis further clarified that the mechanism stemmed from the upregulation of gene expression in pathways such as the Wnt, Hippo, and other signaling pathways.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.409","citationCount":"0","resultStr":"{\"title\":\"Pu-erh tea reduces the transmission of CRD-mediated alopecia risk to offspring\",\"authors\":\"Shanshan Hu, Jie Wang, Zhiyuan Lin, Bowen Zhang, Liyong Luo, Liang Zeng\",\"doi\":\"10.1002/fft2.409\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Circadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu-erh tea, with alleviating effects of CRD-mediated syndrome, can act on the transmission of alopecia risk to offspring is also unproven. Here, we obtained CRD parental mice offspring and found that CRD-mediated alopecia risk can be transmitted to offspring, especially male offspring. Parental consumption of Pu-erh tea, especially in females or both parents, reduced the risk of CRD-mediated alopecia transmitted to offspring by inhibiting subcutaneous fat accumulation (downregulation of Rab18, fat-specific protein 27 (Fsp27), and perilipin 1 (Plin1)), reducing oxidative stress and inflammation in skin tissue (NADPH oxidase 4 (NOX4)/ nuclear factor kappa-B (NF-κB)), balancing androgen and hair growth factor release (hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1)), and restoring hair follicle DNA repair function (upregulation of Ku70, 8-Oxoguanine DNA glycosylase 1 (OGG1), and Rad51). Transcriptomic analysis further clarified that the mechanism stemmed from the upregulation of gene expression in pathways such as the Wnt, Hippo, and other signaling pathways.</p>\",\"PeriodicalId\":73042,\"journal\":{\"name\":\"Food frontiers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.4000,\"publicationDate\":\"2024-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.409\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food frontiers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/fft2.409\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food frontiers","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fft2.409","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
昼夜节律紊乱(CRD)与毛发退行性脱落密切相关,但这种风险是否会遗传给后代尚不清楚。普洱茶具有缓解昼夜节律紊乱综合征的作用,是否能将脱发风险传递给后代也尚未得到证实。在此,我们获得了 CRD 亲本小鼠的后代,并发现 CRD 介导的脱发风险可传递给后代,尤其是雄性后代。通过抑制皮下脂肪堆积(Rab18、脂肪特异性蛋白27(Fsp27)和过脂素1(Plin1)的下调)、减少皮肤组织的氧化应激和炎症(NADPH氧化酶4(NOX4)/核因子卡巴-B(NF-κB)),父母(尤其是雌性或父母双方)饮用普洱茶可降低CRD介导的脱发遗传给后代的风险、平衡雄激素和毛发生长因子的释放(肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)、胰岛素样生长因子 1(IGF-1)),恢复毛囊 DNA 修复功能(上调 Ku70、8-氧鸟嘌呤 DNA 糖基化酶 1(OGG1)和 Rad51)。转录组分析进一步明确了这一机制源于 Wnt、Hippo 和其他信号通路中基因表达的上调。
Pu-erh tea reduces the transmission of CRD-mediated alopecia risk to offspring
Circadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu-erh tea, with alleviating effects of CRD-mediated syndrome, can act on the transmission of alopecia risk to offspring is also unproven. Here, we obtained CRD parental mice offspring and found that CRD-mediated alopecia risk can be transmitted to offspring, especially male offspring. Parental consumption of Pu-erh tea, especially in females or both parents, reduced the risk of CRD-mediated alopecia transmitted to offspring by inhibiting subcutaneous fat accumulation (downregulation of Rab18, fat-specific protein 27 (Fsp27), and perilipin 1 (Plin1)), reducing oxidative stress and inflammation in skin tissue (NADPH oxidase 4 (NOX4)/ nuclear factor kappa-B (NF-κB)), balancing androgen and hair growth factor release (hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1)), and restoring hair follicle DNA repair function (upregulation of Ku70, 8-Oxoguanine DNA glycosylase 1 (OGG1), and Rad51). Transcriptomic analysis further clarified that the mechanism stemmed from the upregulation of gene expression in pathways such as the Wnt, Hippo, and other signaling pathways.