免疫检查点阻断可保护老年小鼠免受感染。

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2024-07-08 DOI:10.1038/s43587-024-00664-6

Daniel Thiele, Nicole L. La Gruta

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引用次数: 0

摘要

一项研究表明，免疫检查点阻断剂能有效延长病原体暴露后老年小鼠的存活时间并增强CD8+ T细胞的功能。这些发现强调了与衰老相关的免疫变化如何可能导致 CD8+ T 细胞对检查点阻断的反应增强，从而改善对感染的保护。这些发现还强调了了解免疫衰老对未来针对老年人的免疫疗法的重要性。

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Immune-checkpoint blockade protects aged mice from infection

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Immune-checkpoint blockade protects aged mice from infection

A study demonstrates the efficacy of immune-checkpoint blockade in prolonging survival and boosting CD8+ T cell function in aged mice after pathogen exposure. These findings highlight how aging-related immune changes may lead to augmented CD8+ T cell responses to checkpoint blockade, which results in improved protection from infection. The findings also highlight the importance of understanding immune aging in future efforts to target immunotherapies to older adults.

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来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

发文量