寻常天疱疮和粘膜天疱疮:临床表现、诊断和治疗的系统回顾。

IF 1.8 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
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引用次数: 0

摘要

寻常型丘疹性荨麻疹(Pemphigus vulgaris,PV)和粘膜丘疹性荨麻疹(Mucous membrane pemphigoid,MMP)是以粘膜和皮肤水疱性病变为特征的粘膜自身免疫性疾病,临床表现非常相似。本研究旨在系统回顾有关寻常型丘疹性荨麻疹(PV)和粘膜丘疹性荨麻疹(MMP)患者的临床和人口统计学特征、诊断方法和治疗的文献。纳入的研究描述了通过直接免疫荧光诊断出的口腔内表现的丘疹性脓疱疮和粘膜丘疹性脓疱疮病例。共纳入 32 篇文章,其中 18 篇研究了口腔黏膜丘疹,15 篇研究了口腔黏膜脓疱病,分别有 50 和 123 个病例被诊断为口腔黏膜丘疹和口腔黏膜脓疱病。大多数 PV(64%)和 MMP(81.3%)患者为女性,年龄分别为五六十岁。在口腔多发性硬化症(71.4%)和口腔黏膜多发性硬化症(91%)中,口腔都是主要受累部位。颊粘膜和牙龈分别是口腔内最常受累的部位,前者为30%,后者为64.2%。在这两种病症的所有病例中,直接免疫荧光均显示 IgG 阳性。口腔多发性硬化症患者的首选治疗方法是全身皮质类固醇治疗(50%),口腔多发性硬化症患者的首选治疗方法是局部治疗(53.7%)。口腔内偏好部位、口腔外受累情况和诊断测试结果的不同,使我们能够追踪 PV 和 MMP 的临床、人口统计学和诊断概况,从而有助于鉴别诊断和治疗管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pemphigus vulgaris and mucous membrane pemphigoid: A systematic review of clinical manifestations, diagnosis, and treatment
Pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP) are mucocutaneous autoimmune diseases characterized by blistering lesions of mucous membranes and skin, with very similar clinical manifestations. This study aimed to systematically review the literature on the clinical and demographic profile, diagnostic methods, and treatment of patients with pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP). Studies describing cases of PV and MMP diagnosed by direct immunofluorescence that exhibited intraoral manifestations were included. Thirty-two articles were included, with 18 studies on PV and 15 on MMP, corresponding to 50 and 123 cases diagnosed as PV and MMP, respectively. Most patients with PV (64 %) and MMP (81.3 %) were women in the fifth and sixth decade of life, respectively. The mouth was the primary site of involvement both in PV (71.4 %) and in MMP (91 %). The cheek mucosa and gingiva were the most frequently affected intraoral sites in PV (30 %) and MMP (64.2 %), respectively. Direct immunofluorescence was positive for IgG in all cases of the two conditions. The treatment of choice was systemic corticosteroid therapy for patients with PV (50 %) and topical treatment for patients with MMP (53.7 %). Differences in intraoral site predilection, extraoral involvement, and the results of diagnostic tests allow us to trace the clinical, demographic, and diagnostic profile of PV and MMP that contributes to differential diagnosis and therapeutic management.
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来源期刊
Journal of Stomatology Oral and Maxillofacial Surgery
Journal of Stomatology Oral and Maxillofacial Surgery Surgery, Dentistry, Oral Surgery and Medicine, Otorhinolaryngology and Facial Plastic Surgery
CiteScore
2.30
自引率
9.10%
发文量
0
审稿时长
23 days
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