脉络丛的免疫和代谢环境是保护大脑的潜在目标。

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-29 DOI:10.1016/j.tins.2024.05.010
Afroditi Tsitsou-Kampeli, Stefano Suzzi, Michal Schwartz
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引用次数: 0

摘要

大脑脉络丛(CP)是一个解剖学和功能上的 "检查点",它调节着大脑和外周之间的交流,并有助于终生维持健康的大脑稳态。来自小鼠模型和人类的证据揭示了 CP 检查点特性的丧失与 CP 免疫环境失调之间的联系,这是各种神经系统疾病的共同特征。我们特别指出,CP 上不同免疫信号(包括 CD4+ T 细胞衍生的细胞因子、I 型干扰素和补体成分)之间的失衡会在衰老和神经变性过程中导致脑部炎症和认知功能退化。此外,我们还强调了脑CP代谢在控制脑CP炎症中的作用,并提出靶向调节脑CP代谢的分子可有效保护大脑功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immune and metabolic milieu of the choroid plexus as a potential target in brain protection.

The brain's choroid plexus (CP), which operates as an anatomical and functional 'checkpoint', regulates the communication between brain and periphery and contributes to the maintenance of healthy brain homeostasis throughout life. Evidence from mouse models and humans reveals a link between loss of CP checkpoint properties and dysregulation of the CP immune milieu as a conserved feature across diverse neurological conditions. In particular, we suggest that an imbalance between different immune signals at the CP, including CD4+ T cell-derived cytokines, type-I interferon, and complement components, can perpetuate brain inflammation and cognitive deterioration in aging and neurodegeneration. Furthermore, we highlight the role of CP metabolism in controlling CP inflammation, and propose that targeting molecules that regulate CP metabolism could be effective in safeguarding brain function.

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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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