前列腺癌的种族差异:基因和分子状况展望。

IF 7.7 2区 医学 Q1 ONCOLOGY
Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-06-20 DOI:10.1007/s10555-024-10193-8
Jyoti B Kaushal, Pratima Raut, Sakthivel Muniyan, Jawed A Siddiqui, Zahraa W Alsafwani, Parthasarathy Seshacharyulu, Sujit S Nair, Ashutosh K Tewari, Surinder K Batra
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引用次数: 0

摘要

前列腺癌(PCa)的发病率、发病率和死亡率受到种族差异的严重影响。尽管采用了创新的治疗方法并在预防方面取得了进展,但与其他种族相比,非裔美国人(AA)男性罹患 PCa 的风险更高,在初次诊断 PCa 时,其病情更具侵袭性和转移性。有关 PCa 的研究强调了种族差异的生物学和分子基础,并强调遗传因素是种族不平等的基本组成部分。此外,AA 族男性和其他少数族裔的入院率较低、进入国家级癌症机构的机会有限以及推迟治疗都是改善 PCa 患者预后的障碍。本综述提供了各种生物学和分子因素的最新信息,如单核苷酸多态性(SNP)、突变谱、染色体位点改变、基因表达差异、转录组分析、表观遗传因素、肿瘤微环境(TME)以及 PCa 种族差异的免疫调节。本综述还强调了未来的研究途径,以探索导致 PCa 种族差异的潜在生物学因素,尤其是在非洲裔男性中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Racial disparity in prostate cancer: an outlook in genetic and molecular landscape.

Racial disparity in prostate cancer: an outlook in genetic and molecular landscape.

Prostate cancer (PCa) incidence, morbidity, and mortality rates are significantly impacted by racial disparities. Despite innovative therapeutic approaches and advancements in prevention, men of African American (AA) ancestry are at a higher risk of developing PCa and have a more aggressive and metastatic form of the disease at the time of initial PCa diagnosis than other races. Research on PCa has underlined the biological and molecular basis of racial disparity and emphasized the genetic aspect as the fundamental component of racial inequality. Furthermore, the lower enrollment rate, limited access to national-level cancer facilities, and deferred treatment of AA men and other minorities are hurdles in improving the outcomes of PCa patients. This review provides the most up-to-date information on various biological and molecular contributing factors, such as the single nucleotide polymorphisms (SNPs), mutational spectrum, altered chromosomal loci, differential gene expression, transcriptome analysis, epigenetic factors, tumor microenvironment (TME), and immune modulation of PCa racial disparities. This review also highlights future research avenues to explore the underlying biological factors contributing to PCa disparities, particularly in men of African ancestry.

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来源期刊
CiteScore
17.00
自引率
0.00%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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