利用气相色谱-质谱法鉴定大麻中的Δ9-四氢大麻酚化合物

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-06-14 DOI:10.46542/pe.2024.246.4349

Gilang Bhakti Nusantara, Tesia Rahmania

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引用次数: 0

摘要

背景：麻醉剂分为天然、半合成和合成三种。大麻属于大麻科，种类为大麻（Cannabis sativa L.）。这种植物因含有主要生物碱大麻酚（cannabinol）、大麻二酚（cannabidiol）和Δ9-四氢大麻酚（Δ9-Tetrahydrocannabinol）而被称为具有精神作用的植物：本研究旨在确定样本中是否含有 Δ9-四氢大麻酚：采用的方法是杜肯诺瓦色素测试法、快蓝法、气相色谱-质谱法（GC-MS）确认法：结果：结果显示，杜昆诺色试验呈阳性，呈蓝色；快速蓝试验呈阳性，呈砖红色。气相色谱-质谱分析表明，Δ9-四氢大麻烷、大麻色素、屈大麻酚、大麻萜酚和大麻酚存在。色谱图显示了五个峰，主要化合物为屈大麻酚：结论：在样本中发现的五种化合物分别为 9-四氢大麻烷、大麻色素、屈大麻酚、大麻萜酚和大麻酚，对大麻呈阳性反应。

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Identification of Δ9-tetrahydrocannabinol compounds in Cannabis sativa using gas chromatography-mass spectrometry

Background: Narcotics are divided into three types natural, semisynthetic and synthetic. Cannabis is included in the Cannabaceae family with the species Cannabis sativa L. This plant is known as a plant that has psychotropic effects because it contains the main alkaloids cannabinol, cannabidiol, and Δ9-Tetrahydrocannabinol. Objective: This study aims to identify the presence of Δ9-Tetrahydrocannabinol in samples. Method: The method used is the Duquenois colour test, Fast Blue, Gas Chromatography-Mass Spectrometry (GC-MS) confirmation. Result: The result shows that Dequenoise test positive giving a blue color and Fast Blue color test positive giving a brick red. The GC-MS analysis shows the presence of Δ9-Tetrahidrocannabivarin, Cannabichrome, Dronabinol, Cannabigerol, and Cannabinol. The chromatogram revealed five peaks, with the main compound identified as dronabinol. Conclusion: Five compounds found in sample were 9-tetrahydrocannabivarin, cannabichromene, dronabinol, cannabigerol, and cannabinol, which were positive for marijuana.

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.